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Updated: Apr 28, 2026

Basophil Activation Test for Allergy Diagnosis

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Published on: May 31, 2021

Allergen-Specific Immunotherapy in Asthma.

¹Department of Clinical Immunology, Wrocław Medical University, Wroclaw, Poland ; ALL-MED Medical Research Institute, Wroclaw, Poland.

Current Treatment Options in Allergy

|June 6, 2014

Summary

This summary is machine-generated.

Allergen-specific immunotherapy (AIT) modifies allergic asthma by addressing immune dysregulation, unlike current therapies. Both subcutaneous (SCIT) and sublingual (SLIT) AIT show effectiveness in clinical trials.

Keywords:

Allergen-specific immunotherapy Asthma Bronchodilators Inhaled corticosteroids LABA Long acting bronchodilators Omalizumab SCIT SLIT

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Area of Science:

Immunology
Allergy Research
Respiratory Medicine

Background:

Current asthma treatments manage symptoms and inflammation but do not alter the underlying immune response, leading to disease relapse upon cessation.
Allergen-specific immunotherapy (AIT) is the sole etiological treatment offering disease modification for asthma.
Recent research elucidates AIT's mechanisms, including desensitization, immune tolerance, and reduced allergic inflammation.

Approach:

Review of current evidence on allergen-specific immunotherapy (AIT) for allergic asthma.
Analysis of clinical trial data for subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT).
Evaluation of AIT's impact on symptom scores, medication use, quality of life, and immunological markers.

Key Points:

Both SCIT and SLIT are effective in improving asthma control and quality of life.
AIT induces specific immunological changes, suggesting a disease-modifying effect.
Current guidelines conditionally recommend AIT, acknowledging moderate to low evidence quality.

Conclusions:

While both SCIT and SLIT demonstrate efficacy, head-to-head comparative studies are limited.
Variability in study endpoints prevents definitive conclusions on the superiority of either administration route.
Further research is needed to directly compare SCIT and SLIT and establish optimal treatment protocols.