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Updated: Apr 28, 2026
Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
Published on: March 24, 2023
Contrast between hypervascularized liver lesions and hepatic parenchyma: early dynamic PET versus contrast-enhanced
Martin Freesmeyer1, Thomas Winkens, Jan-Henning Schierz
1Clinic of Nuclear Medicine, Jena University Hospital, Bachstrasse 18, 07740, Jena, Germany, martin.freesmeyer@med.uni-jena.de.
Objectives:
To detect hypervascularized liver lesions, early dynamic (ED) (18)F-FDG PET may be an alternative when contrast-enhanced (CE) imaging is infeasible. This retrospective pilot analysis compared contrast between such lesions and liver parenchyma, an important objective image quality variable, in ED PET versus CE CT.
Materials And Methods:
Twenty-eight hypervascularized liver lesions detected by CE CT [21 (75%) hepatocellular carcinomas; mean (range) diameter 4.9 ± 3.5 (1-14) cm] in 20 patients were scanned with ED PET. Using regions of interest, maximum and mean lesional and parenchymal signals at baseline, arterial and venous phases were calculated for ED PET and CE CT.
Results:
Lesional/parenchymal signal ratio was significantly higher (P < 0.005) with ED PET versus CE CT at the arterial phase and similar between the methods at the venous phase.
Conclusion:
In liver imaging, ED PET generates greater lesional-parenchymal contrast during the arterial phase than does CE CT; these observations should be formally, prospectively evaluated.
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