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Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET

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Related Experiment Video

Updated: Jun 27, 2026

Management of Respiratory Motion Artefacts in 18F-fluorodeoxyglucose Positron Emission Tomography using an Amplitude-Based Optimal Respiratory Gating Algorithm
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Management of Respiratory Motion Artefacts in 18F-fluorodeoxyglucose Positron Emission Tomography using an Amplitude-Based Optimal Respiratory Gating Algorithm

Published on: July 23, 2020

Minimal-Activity 18F-FDG PET/CT as a Potential Problem-Solving Tool in a Patient with Suspected Lung Cancer

Theresa Leder1, Nathalie Viohl1, Christian Kühnel1

  • 1Clinic of Nuclear Medicine, Jena University Hospital, 07747 Jena, Germany.

Diagnostics (Basel, Switzerland)
|June 26, 2026
PubMed
Summary

Minimal activity (MA) PET/CT clarified a lung nodule in a non-small cell lung cancer patient, classifying it as inflammatory. This technique offers valuable metabolic insights for suspected cancer recurrence with low radiation exposure.

Keywords:
18F-FDGcancer stagingminimal activitynon-small cell lung cancerradiation exposuresegmental PET/CT

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Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
06:51

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Published on: July 21, 2018

Area of Science:

  • Oncology
  • Nuclear Medicine
  • Radiology

Background:

  • Non-small cell lung cancer (NSCLC) recurrence requires accurate diagnostic methods.
  • 18F-FDG PET/CT is a standard imaging modality for detecting cancer recurrence.
  • Distinguishing between malignant and inflammatory lung nodules can be challenging.

Purpose of the Study:

  • To evaluate the utility of segmental minimal activity (MA) PET/CT in a patient with suspected non-small cell lung cancer recurrence.
  • To assess the ability of MA-PET/CT to differentiate between malignant and inflammatory lung nodules.
  • To report on a rare application of MA-PET/CT in lung cancer follow-up.

Main Methods:

  • A 74-year-old woman with a history of NSCLC underwent standard whole-body 18F-FDG PET/CT.
  • An indeterminate lung nodule was further investigated using segmental minimal activity (MA) PET/CT.
  • Clinical findings were integrated with MA-PET/CT results for nodule classification.

Main Results:

  • The whole-body 18F-FDG PET/CT revealed an indeterminate lung nodule.
  • Segmental MA-PET/CT provided additional metabolic information for clarification.
  • The nodule was ultimately classified as inflammatory based on MA-PET/CT and clinical data.

Conclusions:

  • Segmental minimal activity (MA) PET/CT can be a valuable tool for clarifying indeterminate lung nodules in patients with a history of non-small cell lung cancer.
  • This technique offers enhanced metabolic assessment with minimal radiation increase.
  • The use of MA-PET/CT for suspected lung cancer recurrence is infrequently reported and warrants further investigation.