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Updated: Apr 28, 2026
Split Hybridization Probe Utilizing a DNA Fluorescent Light-up Aptamer as a Signal Reporter for Sequence-Specific Nucleic Acid Analysis
Published on: July 8, 2025
A self-assembled conformational switch: a host-guest stabilized triple stem molecular beacon via a photoactivated and
Leiliang He1, Xiaohai Yang, Kemin Wang
1State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University, Changsha 410082, China. kmwang@hnu.edu.cn.
Abstract:
We present a novel strategy for construction of a conformational switch of a molecular beacon based on the combination of nucleic acid (DNA) self-assembly and reversible host-guest inclusion interaction. With the functionalized probe, the nucleic acid hybridization process can be easily controlled with a photoactivated and thermal regeneration mode.
