Cardiac, Macro-, and Micro-Circulatory Abnormalities in Association With Individual Metabolic Syndrome Component: The
Fang Zhao1, Rong Yang1, Rusitanmujiang Maimaitiaili2
1Department of Geriatrics, Shanghai Putuo People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Frontiers in Cardiovascular Medicine
|July 26, 2021
Summary
Metabolic syndrome (MS) is linked to heart and blood vessel problems in older Chinese adults. Individual components of MS also show specific links to these circulatory issues, highlighting their prognostic importance.
Area of Science:
- Gerontology
- Cardiovascular Medicine
- Metabolic Disorders
Background:
- Metabolic syndrome (MS) is a cluster of conditions that increase the risk of heart disease, stroke, and diabetes.
- Cardiovascular abnormalities, including cardiac, macro- and micro-circulatory impairments, are prevalent in elderly populations.
Purpose of the Study:
- To investigate the association between metabolic syndrome (MS) and its components with cardiovascular abnormalities in elderly Chinese individuals.
- To identify specific associations between individual MS components and various circulatory impairments.
Main Methods:
- Cross-sectional study of 1,958 Chinese participants aged over 65 from the Northern Shanghai Study.
- MS defined by NCEPIII 2005 criteria; evaluated parameters included LVMI, E/Ea, cf-PWV, ABI, CIMT, arterial plaque, and UACR.
- Logistic regression analysis used to determine associations between MS, its components, and cardiovascular abnormalities.
Main Results:
- Increasing MS components correlated with higher LVMI, E/Ea, cf-PWV, and UACR, and lower ABI (p < 0.01).
- MS was significantly associated with LV hypertrophy, diastolic dysfunction, arteriosclerosis, and microalbuminuria (p < 0.001).
- Central obesity and hypertension linked to all abnormalities; elevated glucose to arteriosclerosis/microalbuminuria; high triglycerides to microalbuminuria.
Conclusions:
- Metabolic syndrome is significantly associated with cardiac, macro-, and micro-circulatory abnormalities in the elderly Chinese population.
- Individual components of MS possess distinct prognostic significance for cardiovascular health.
Keywords:
cardiac abnormalityelderly populationmacrocirculatory abnormalitymetabolic syndromemicrocirculatory abnormalityMore Related Videos
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