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Correlation between red blood cell distribution width and deep vein thrombosis in patients with lower limb fractures
Shuai Ji1, Hongfei Qi1, Zhong Li1
1Department of Traumatic Orthopedics, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Objective:
This study aimed to investigate the relationship between red blood cell distribution width (RDW) and perioperative lower-extremity deep vein thrombosis (DVT) in patients aged 18-75 years with lower-limb fractures.
Material And Methods:
From February 2021 to February 2023, we included 766 patients aged 18-75 years with lower-limb fractures. Univariate and multivariable analyses were used to investigate the association between RDW and DVT. The discriminatory ability and cohort-specific exploratory cut-off values of RDW were evaluated using receiver operating characteristic (ROC) curves.
Results:
ROC curve analysis identified cohort-specific exploratory cut-off values of 43.9 fL for RDW standard deviation (RDW-SD) and 13.2% for RDW coefficient of variation (RDW-CV), and RDW-SD showed better discrimination than RDW-CV (P < 0.05). In the adjusted analyses, RDW-SD ≥43.9 fL [adjusted odds ratio (aOR), 3.372; P < 0.001], RDW-CV ≥13.2% (aOR, 2.556; P < 0.001), advanced age (aOR, 1.054; P < 0.001), higher platelet count (PLT; per 10 × 10⁹/L increase: aOR, 1.115; P = 0.010), and Hb <120 g/L (aOR, 1.785; P < 0.001) were independently associated with perioperative DVT. Significant differences in age, fracture site, DVT, diabetes, cancer, and Hb <120 g/L were observed between the RDW-SD ≥43.9 fL and RDW-SD <43.9 fL groups (all P < 0.05).
Conclusion:
Advanced age, Hb <120 g/L, higher PLT, RDW-SD ≥43.9 fL, and RDW-CV ≥13.2% were independently associated with perioperative DVT in patients aged 18-75 years with lower-limb fractures. RDW-SD showed better discrimination than RDW-CV.
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