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[Purulent meningitis. Presentation of 47 cases]
Abstract:
We report 47 patients with purulent meningitis who were seen at our institution during the last 3 years. In 42.5% of patients an upper respiratory infection previous to the onset of the clinical features of meningitis was demonstrated. We had positive bacteriological results in 47% of cases. In the remaining patients the culture was negative. 56% of these had received previous antibiotic therapy. Only 4 patients died, all of them with initial septic shock. The therapy of choice was i.v. ampicillin, at a dose of 1-3 g/4 hours.
Insights
This study analyzed 47 purulent meningitis cases, finding upper respiratory infections preceded over 40% of cases. Intravenous ampicillin was the preferred treatment, with a low mortality rate observed.
Area of Science:
- Infectious Diseases
- Neurology
- Bacteriology
Context:
- Purulent meningitis presents a significant clinical challenge.
- Understanding predisposing factors and treatment outcomes is crucial for patient management.
- This study reviews a recent cohort of meningitis patients.
Purpose:
- To analyze the clinical features, bacteriological findings, and treatment outcomes of purulent meningitis.
- To identify predisposing factors, such as upper respiratory infections.
- To evaluate the efficacy of intravenous ampicillin therapy.
Summary:
- A retrospective analysis of 47 purulent meningitis patients over three years.
- 42.5% had preceding upper respiratory infections; 47% yielded positive bacterial cultures.
- Intravenous ampicillin (1-3g every 4 hours) was the primary therapy, with 4 deaths, all due to septic shock.
Impact:
- Highlights the association between upper respiratory infections and purulent meningitis.
- Demonstrates the effectiveness of intravenous ampicillin in treating purulent meningitis.
- Provides insights into mortality factors, emphasizing septic shock as a critical complication.