[Bacteriuria caused by Streptococcus pneumoniae].

Area of Science:

• Urology
• Infectious Diseases
• Nephrology

Background:

• Urinary tract infections (UTIs) are common in renal transplant recipients.
• Understanding the prevalence and antimicrobial susceptibility of pathogens like Streptococcus pneumoniae is crucial for patient management.

Purpose of the Study:

• To investigate the occurrence of Streptococcus pneumoniae in urine samples from renal transplant patients compared to non-transplanted individuals.
• To determine the antibiotic resistance patterns of isolated Streptococcus pneumoniae strains.

Main Methods:

• Retrospective analysis of urine cultures from 451 renal transplant patients and 2,943 non-transplanted patients.
• Identification of Streptococcus pneumoniae and assessment of its colony counts (CFU/ml).
• Antimicrobial susceptibility testing for common antibiotics including penicillin, co-trimoxazole, norfloxacin, nitrofurantoin, and rifampin.

Main Results:

• Streptococcus pneumoniae was detected in 4.9% of renal transplant patients versus 0.8% of non-transplanted patients (p < 0.001).
• Isolated strains showed high resistance rates: 47.8% to penicillin, 56.5% to co-trimoxazole, and 60% to norfloxacin.
• All strains were susceptible to nitrofurantoin and rifampin.

Conclusions:

• Renal transplant recipients have a significantly higher prevalence of Streptococcus pneumoniae in urine.
• The high rates of resistance to common antibiotics necessitate careful selection of treatment.
• Nitrofurantoin and rifampin represent effective treatment options against these strains.