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Updated: Apr 28, 2026
Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
Published on: March 12, 2015
Organometallic nucleoside analogues with ferrocenyl linker groups: synthesis and cancer cell line studies
Huy V Nguyen1, Antoine Sallustrau, Jan Balzarini
1School of Chemistry, ‡School of Cancer Sciences, College of Medical and Dental Sciences, §School of Biosciences, College of Life and Environmental Sciences, and ∥School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham , Edgbaston, Birmingham, B15 2TT, U.K.
Abstract:
Examples of organometallic compounds as nucleoside analogues are rare within the field of medicinal bioorganometallic chemistry. We report on the synthesis and properties of two chiral ferrocene derivatives containing a nucleobase and a hydroxyalkyl group. These so-called ferronucleosides show promising anticancer activity, with cytostatic studies on five different cancer cell lines indicating that both functional groups are required for optimal activity.
