Related Experiment Video
Updated: Apr 28, 2026
07:00
Dual Effects of Melanoma Cell-derived Factors on Bone Marrow Adipocytes Differentiation
Published on: August 23, 2018
5.2K
Adiponectin induces breast cancer cell migration and growth factor expression
Zhongming Jia1, Yan Liu, Shouyong Cui
1Department of Thyroid and Breast Surgery, Affiliated Hospital of Binzhou Medical College, Binzhou, 256610, People's Republic of China, jxy1216295@sina.com.
Cell Biochemistry and Biophysics
|June 8, 2014
Summary
Adiponectin, a hormone from fat cells, significantly boosts breast cancer cell growth and migration by increasing growth factors. Elevated adiponectin levels may indicate a higher breast cancer risk, especially with obesity.
Area of Science:
- Endocrinology
- Oncology
- Cell Biology
Background:
- Adiponectin, secreted by adipocytes, influences cell migration and angiogenesis.
- Its role in breast cancer progression requires further investigation.
Purpose of the Study:
- To investigate adiponectin's effect on breast cancer cell migration and growth factor expression in vitro.
- To determine if adiponectin influences estrogen-independent breast cancer cell lines.
Main Methods:
- Breast cancer cell lines (MDA-MB-436, MFM-223) were treated with adiponectin.
- Growth factor expression was measured using ELISA.
- Cell migration was assessed using Transwell systems and kinase inhibitors.
Main Results:
- Adiponectin significantly increased expression of vascular endothelial growth factor, transforming growth factor-β1, and basic fibroblast growth factor.
- Adiponectin enhanced breast cancer cell migration, with inhibition observed using MAPK and PI3K pathway inhibitors.
- These findings were consistent in both tested estrogen-independent cell lines.
Conclusions:
- Adiponectin promotes breast cancer cell growth and migration through growth factor induction.
- Adiponectin's role in promoting these effects suggests it may be a risk factor for breast cancer progression.
- Obesity-associated changes in adiponectin levels could be a significant risk factor for breast cancer patients.
Related Concept Videos
01:35Cancer Cell Migration through Invadopodia
2.5K
Invadosome is a broad category of cell surface structures with proteolytic activity that degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
2.5K
02:38Mitogens and the Cell Cycle
6.3K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.3K
03:03mTOR Signaling and Cancer Progression
3.6K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.6K
01:22PI3K/mTOR/AKT Signaling Pathway
5.1K
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...
5.1K
01:17Intracellular Signaling Affects Focal Adhesions
2.7K
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Some...
2.7K
01:15Activation of Integrins
4.3K
Integrins bind ligands and transmit information from outside the cell to inside or vice-versa through an "outside-in signaling" or "inside-out signaling."
In "outside-in signaling," external factors in the extracellular space bind to exposed ligand binding sites on integrins. This causes the inactive protein to undergo a conformational change to become active. Integrins are often clustered on the cell membrane. Repetitive and regularly spaced ligand binding...
In "outside-in signaling," external factors in the extracellular space bind to exposed ligand binding sites on integrins. This causes the inactive protein to undergo a conformational change to become active. Integrins are often clustered on the cell membrane. Repetitive and regularly spaced ligand binding...
4.3K