Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Cell Cycle Control System

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...

The Cell Cycle Control System

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...

The Cell Cycle Control System

The Cell Cycle Control System

Replicative Cell Senescence

Replicative Cell Senescence

Replicative Cell Senescence

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...

Negative Regulator Molecules

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Alpha-Gal Syndrome: Unrecognized Risks of a Tick-Bite-Associated Allergy in Transplantation and Cellular Therapy.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026

Same author

Senescent and reactive astrocytes display distinct expression profiles and divergent functional capacities.

bioRxiv : the preprint server for biology·2026

Same author

Adenosine deaminase co-immunization reverses age-associated immunosenescence by restoring germinal center T follicular helper cell function.

bioRxiv : the preprint server for biology·2026

Same author

Trends in cryoprecipitate transfusion in the United States.

Transfusion·2026

Same author

"We have traveled into the past, which had already stretched out its shadows towards me" - What patients experience as helpful in two trauma-focused psychotherapies for PTSD related to childhood maltreatment.

Child abuse & neglect·2026

Same author

The clinical use of cryoprecipitate and fibrinogen concentrate: A scoping review.

Transfusion·2026

Same journal

Nanotechnology-Stem Cell Strategies in 3D Glioblastoma Organoid: Targeting Glioma Stem Cells Within a Complex Tumor Microenvironment.

Methods in molecular biology (Clifton, N.J.)·2026

Same journal

Mapping the 3D Chromosome Organization of a Biosynthetic Gene Cluster by Capture Hi-C (CHi-C).

Methods in molecular biology (Clifton, N.J.)·2026

Same journal

Mapping the 3D Chromosome Organization of Streptomyces by Hi-C.

Methods in molecular biology (Clifton, N.J.)·2026

Same journal

CUT&Tag Epigenomic Profiling of Biosynthetic Gene Clusters in Arabidopsis thaliana.

Methods in molecular biology (Clifton, N.J.)·2026

Same journal

Rhizobium rhizogenes-Mediated Hairy Root Transformation Protocol for Lotus japonicus and Other Legumes.

Methods in molecular biology (Clifton, N.J.)·2026

Same journal

Characterization of Bioactive Saponins from Sea Cucumbers.

Methods in molecular biology (Clifton, N.J.)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 28, 2026

Techniques to Induce and Quantify Cellular Senescence

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

The senescence arrest program and the cell cycle.

Alessandro Bitto¹, Elizabeth P Crowe, Chad Lerner

¹Department of Pathology, University of Washington, Health Science Building D-514, Seattle, 357470, WA, USA.

Methods in Molecular Biology (Clifton, N.J.)

|June 8, 2014

Summary

This summary is machine-generated.

Cellular senescence, a stress response to damage, is a key factor in organismal aging. This review explores its role in aging and disease, linking cellular damage to the aging process.

More Related Videos

Generation and Isolation of Cell Cycle-arrested Cells with Complex Karyotypes

Generation and Isolation of Cell Cycle-arrested Cells with Complex Karyotypes

Published on: April 13, 2018

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

Published on: September 26, 2025

Related Experiment Videos

Last Updated: Apr 28, 2026

Techniques to Induce and Quantify Cellular Senescence

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

Generation and Isolation of Cell Cycle-arrested Cells with Complex Karyotypes

Generation and Isolation of Cell Cycle-arrested Cells with Complex Karyotypes

Published on: April 13, 2018

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

Published on: September 26, 2025

Area of Science:

Gerontology and Cellular Biology
Molecular Biology and Pathology

Background:

Aging is a universal biological process involving progressive functional decline and tissue damage.
Cellular senescence, a stress-induced cell cycle arrest, is implicated in aging due to accumulated cellular damage.
Initially observed in vitro, senescence is increasingly recognized in various pathological conditions.

Purpose of the Study:

To review the key aspects of the cellular senescence program.
To examine the interrelationships between senescence, damage arrest pathways, and the cell cycle.
To discuss the impact and relevance of senescence in vivo.

Main Methods:

Literature review and synthesis of existing research on cellular senescence.
Analysis of the molecular mechanisms underlying senescence induction.
Examination of evidence for senescence in pathological settings and aging.

Main Results:

Cellular senescence is a conserved stress-response pathway triggered by DNA damage, protein aggregation, and organelle dysfunction.
Senescence plays a complex role in aging and disease, potentially acting as both a protective and detrimental mechanism.
The senescence program is intricately linked with cell cycle regulation and broader damage response pathways.

Conclusions:

Cellular senescence is a fundamental process influencing aging and disease pathogenesis.
Understanding senescence mechanisms is crucial for developing interventions targeting age-related decline and pathology.
Further research is needed to fully elucidate the in vivo consequences of senescence.