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Related Concept Videos

The Cell Cycle Control System01:28

The Cell Cycle Control System

5.1K
The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
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The Cell Cycle Control System02:11

The Cell Cycle Control System

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The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
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The Cell Cycle Control System02:11

The Cell Cycle Control System

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Molecular Factors Affecting Cell Division01:27

Molecular Factors Affecting Cell Division

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Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
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Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

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The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
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Negative Regulator Molecules01:23

Negative Regulator Molecules

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Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
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Related Experiment Video

Updated: Apr 28, 2026

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
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Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice

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Cell cycle regulation during viral infection.

Sumedha Bagga1, Michael J Bouchard

  • 1Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, 245 N 15th Street, MS 497, Philadelphia, PA, 19102, USA.

Methods in Molecular Biology (Clifton, N.J.)
|June 8, 2014
PubMed
Summary

Viruses manipulate host cell cycles for replication, using strategies like cell cycle entry or arrest. These viral tactics can lead to disease, including cancer.

Area of Science:

  • Virology
  • Cell Biology
  • Molecular Biology

Background:

  • Viruses depend on host cell machinery for replication.
  • Many viruses subvert host cell cycle controls to create favorable conditions.
  • Viral manipulation of cell cycles can impact host cell physiology and disease.

Purpose of the Study:

  • To summarize viral strategies for modulating host cell replication cycles.
  • To describe how viral effects on cell cycles influence viral replication and disease.

Main Methods:

  • Review of scientific literature on viral strategies.
  • Analysis of viral protein interactions with cell cycle regulators.
  • Correlation of cell cycle modulation with viral replication and pathogenesis.

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Analysis of Cell Cycle Position in Mammalian Cells
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Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
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Analysis of Cell Cycle Position in Mammalian Cells
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Analysis of Cell Cycle Position in Mammalian Cells

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Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
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Main Results:

  • Viruses employ diverse strategies, including inducing cell cycle entry or arrest.
  • DNA and RNA viruses encode proteins targeting cell cycle regulators.
  • Viral manipulation can enhance viral replication but may cause detrimental cellular effects.

Conclusions:

  • Viral modulation of host cell cycles is crucial for viral replication and pathogenesis.
  • Understanding these mechanisms offers insights into virus-associated diseases, including cancer.