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Diffusion tensor imaging of the sural nerve in normal controls.

Boklye Kim1, Ashok Srinivasan1, Brian Sabb2

  • 1Department of Radiology, University of Michigan, Ann Arbor, Michigan.

Clinical Imaging
|June 9, 2014
PubMed
Summary
This summary is machine-generated.

A new diffusion tensor imaging (DTI) protocol effectively images the sural nerve in healthy individuals. This method establishes normative fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values for potential use in patient diagnostics.

Keywords:
Diffusion tensor imagingFractional anisotropyImage registrationSural nerve

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Area of Science:

  • Neuroimaging
  • Medical Imaging
  • Biomedical Engineering

Background:

  • Sural nerve assessment is crucial for diagnosing peripheral neuropathies.
  • Diffusion Tensor Imaging (DTI) offers advanced capabilities for visualizing nerve microstructure.
  • Standardized DTI protocols are needed for reliable sural nerve evaluation.

Purpose of the Study:

  • To develop and validate a Diffusion Tensor Imaging (DTI) protocol for imaging the sural nerve.
  • To establish normative diffusion parameters for the sural nerve in healthy subjects.
  • To assess the feasibility of using DTI for non-invasive sural nerve examination.

Main Methods:

  • DTI scans of sural nerves were performed on 25 healthy controls at 3T.
  • Imaging utilized 6, 15, and 32 gradient directions with specific coronal resolution (0.5x2.0x0.5 mm³).
  • Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were calculated from nerve regions of interest.

Main Results:

  • The developed DTI protocol successfully localized the sural nerve.
  • FA maps demonstrated reduced variability with 32 gradient directions (0.559 ± 0.071) compared to 15 (0.590 ± 0.080) and 6 (0.659 ± 0.109).
  • Normative FA and ADC values were established for the healthy sural nerve.

Conclusions:

  • The DTI protocol is effective for imaging the sural nerve in healthy controls.
  • This protocol provides a basis for establishing normative FA/ADC values.
  • The DTI approach holds potential for non-invasive assessment of diseased sural nerves in patients.