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Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
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Related Experiment Video

Updated: Apr 28, 2026

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
07:42

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Published on: April 26, 2012

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[Neurologic disorder complicating a cervical cancer].

E Hottois, L Weichselbaum, F Guérisse

    Revue Medicale De Bruxelles
    |June 10, 2014
    PubMed
    Summary

    This case study highlights marantic endocarditis, a rare cardiac complication in a patient with cervical adenocarcinoma. Early diagnosis and anticoagulation improved neurological and cardiac symptoms.

    Area of Science:

    • Cardiology
    • Oncology
    • Neurology

    Background:

    • A 47-year-old female patient with stage IIIb cervical adenocarcinoma presented with neurological deficits including visual disturbances and paresthesia.
    • Initial investigations for the neurological symptoms revealed bilateral cerebral lesions of unknown etiology.

    Observation:

    • The patient's condition deteriorated neurologically and cardially despite empirical antibiotic treatment for suspected infectious endocarditis.
    • Serial echocardiography identified a mitral valve nodule, prompting consideration of non-bacterial thrombotic endocarditis.

    Findings:

    • Given the patient's malignancy, negative blood cultures, and serologies, a diagnosis of marantic endocarditis was established.
    • This rare complication, typically associated with advanced cancers, was observed in the context of cervical adenocarcinoma.

    Related Experiment Videos

    Last Updated: Apr 28, 2026

    Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
    07:42

    Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

    Published on: April 26, 2012

    18.1K

    Implications:

    • The case underscores the importance of considering marantic endocarditis in cancer patients with unexplained neurological and cardiac symptoms.
    • Anticoagulant therapy was initiated, leading to initial clinical improvement, highlighting a potential management strategy for this rare condition.