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Related Experiment Video

Updated: Apr 28, 2026

Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion
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Artificial liver.

Norman L Sussman1, James H Kelly2

  • 1Department of Surgery, Baylor College of Medicine, Houston, Texas.

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
|June 10, 2014
PubMed
Summary
This summary is machine-generated.

No true artificial liver devices are available yet, despite significant investment. Future success depends on rigorous testing and appropriate clinical application for failing livers, but not portal hypertension.

Keywords:
Acute Liver FailureArtificial LiverBioartificial LiverExtracorporeal Liver Assist Device

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Area of Science:

  • Biomedical Engineering
  • Hepatology
  • Regenerative Medicine

Background:

  • Artificial liver devices are broadly categorized as inert or cell-based.
  • Cell-based systems represent true artificial livers, aiming to replicate native liver function.
  • Current challenges include rigorous testing and clinical trial performance, with no approved devices available.

Purpose of the Study:

  • To review the current state and future prospects of artificial liver development.
  • To identify key factors for the successful clinical implementation of artificial liver technologies.

Main Methods:

  • Literature review of artificial liver research and development.
  • Analysis of clinical trial outcomes and limitations.
  • Discussion of technical requirements and clinical applicability.

Main Results:

  • No artificial liver device has met expectations in rigorous clinical trials.
  • Existing devices face challenges in achieving sufficient liver function or demonstrating efficacy.
  • Extracorporeal devices can support failing livers but do not address portal hypertension.

Conclusions:

  • Successful artificial liver technology requires both technical advancement and appropriate clinical integration.
  • Future development must focus on rigorous validation and targeted application in specific patient populations.
  • The field's progress hinges on addressing technical hurdles and defining precise clinical use cases.