Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Systematic Error: Methodological and Sampling Errors01:15

Systematic Error: Methodological and Sampling Errors

8.7K
In the case of systematic errors, the sources can be identified, and the errors can be subsequently minimized by addressing these sources. According to the source, systematic errors can be divided into sampling, instrumental, methodological, and personal errors.
Sampling errors originate from improper sampling methods or the wrong sample population. These errors can be minimized by refining the sampling strategy. Defective instruments or faulty calibrations are the sources of instrumental...
8.7K
Random and Systematic Errors01:20

Random and Systematic Errors

11.2K
Scientists always try their best to record measurements with the utmost accuracy and precision. However, sometimes errors do occur. These errors can be random or systematic. Random errors are observed due to the inconsistency or fluctuation in the measurement process, or variations in the quantity itself that is being measured. Such errors fluctuate from being greater than or less than the true value in repeated measurements. Consider a scientist measuring the length of an earthworm using a...
11.2K
Random and Systematic Errors01:20

Random and Systematic Errors

974
974
Imperfections in Crystal Structure: Non-Stoichiometric Defects01:29

Imperfections in Crystal Structure: Non-Stoichiometric Defects

113
Non-stoichiometric defects refer to a type of defect in the crystal structure of a compound where the ratio of its constituent elements deviates from the ideal stoichiometric ratio. There are two main types of non-stoichiometric defects: metal excess defects and metal deficiency defects.Metal excess defects occur when there is a slight surplus of metal ions than what is required by the stoichiometric ratio of the compound. For example, heating a sodium chloride crystal in sodium vapor results...
113
Improving Translational Accuracy02:07

Improving Translational Accuracy

11.5K
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
11.5K
Improving Translational Accuracy02:07

Improving Translational Accuracy

2.6K
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Different Appearances of Esophageal Squamous Cell Carcinoma in 18 F-PSMA PET/CT Versus 18 F-FDG PET/CT.

Clinical nuclear medicine·2025
Same author

Reply: On Facilitating the End of the Linear No-Threshold Era.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2025
Same author

Facilitating the End of the Linear No-Threshold Model Era.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2024
Same author

COVID-19 Vaccine-Related Local FDG Uptake.

Clinical nuclear medicine·2021
Same author

The Risk of Cancer from CT Scans and Other Sources of Low-Dose Radiation: A Critical Appraisal of Methodologic Quality.

Prehospital and disaster medicine·2020
Same author

Comment on 'Implications of recent epidemiologic studies for the linear nonthreshold model and radiation protection'.

Journal of radiological protection : official journal of the Society for Radiological Protection·2019
Same journal

Retraction: Flucytosine and Amphotericin B Coadministration Induces Dose-Related Renal Injury.

Dose-response : a publication of International Hormesis Society·2026
Same journal

miRNA-Targeted Herbal Compounds Against Gastric Precancerous Evolution in Chronic Atrophic Gastritis.

Dose-response : a publication of International Hormesis Society·2026
Same journal

Plant-Mediated Fabrication of Iron and Zinc Oxide Nanoparticles for Anticancer Efficacy Against HT-29 and HepG2 Cells.

Dose-response : a publication of International Hormesis Society·2026
Same journal

Total <i>Sanghuangporus vaninii</i> Extract Ameliorates Cisplatin-Induced Glioma Cell Death by Regulating Ferroptosis and Inflammation.

Dose-response : a publication of International Hormesis Society·2026
Same journal

Causal Association Between Gut Microbiota, Plasma Metabolites, and Prostate Cancer: Two-Step Mendelian Randomization Study.

Dose-response : a publication of International Hormesis Society·2026
Same journal

DMSO Protects Against Radiation-Induced Ovarian Injury by Preserving Mitochondrial Function and Alleviating DNA Damage.

Dose-response : a publication of International Hormesis Society·2026
See all related articles

Related Experiment Video

Updated: Apr 28, 2026

Leveraging CyVerse Resources for De Novo Comparative Transcriptomics of Underserved Non-model Organisms
10:41

Leveraging CyVerse Resources for De Novo Comparative Transcriptomics of Underserved Non-model Organisms

Published on: May 9, 2017

9.9K

Correcting systemic deficiencies in our scientific infrastructure.

Mohan Doss1

  • 1Fox Chase Cancer Center.

Dose-Response : a Publication of International Hormesis Society
|June 10, 2014
PubMed
Summary
This summary is machine-generated.

Scientific progress stalled due to unverified linear no-threshold model, preventing study of radiation hormesis. This likely caused over 15 million preventable cancer deaths, highlighting systemic flaws in applying scientific methods.

Keywords:
LNT ModelRadiation HormesisScientific InfrastructureScientific Method

More Related Videos

gP2S, an Information Management System for CryoEM Experiments
13:01

gP2S, an Information Management System for CryoEM Experiments

Published on: June 10, 2021

5.3K
An Open Source Technology Platform to Manufacture Hydrogel-Based 3D Culture Models in an Automated and Standardized Fashion
08:29

An Open Source Technology Platform to Manufacture Hydrogel-Based 3D Culture Models in an Automated and Standardized Fashion

Published on: March 31, 2022

5.3K

Related Experiment Videos

Last Updated: Apr 28, 2026

Leveraging CyVerse Resources for De Novo Comparative Transcriptomics of Underserved Non-model Organisms
10:41

Leveraging CyVerse Resources for De Novo Comparative Transcriptomics of Underserved Non-model Organisms

Published on: May 9, 2017

9.9K
gP2S, an Information Management System for CryoEM Experiments
13:01

gP2S, an Information Management System for CryoEM Experiments

Published on: June 10, 2021

5.3K
An Open Source Technology Platform to Manufacture Hydrogel-Based 3D Culture Models in an Automated and Standardized Fashion
08:29

An Open Source Technology Platform to Manufacture Hydrogel-Based 3D Culture Models in an Automated and Standardized Fashion

Published on: March 31, 2022

5.3K

Area of Science:

  • Radiation biology
  • Cancer research
  • Scientific methodology

Background:

  • Scientific progress relies on testing competing hypotheses.
  • The linear no-threshold (LNT) model has guided radiation protection policy.
  • Radiation hormesis, a hypothesis suggesting low-dose radiation benefits, has been difficult to study.

Purpose of the Study:

  • To examine how adherence to an unverified hypothesis (LNT model) hindered research into radiation hormesis.
  • To identify systemic deficiencies in the scientific infrastructure for applying scientific methods.
  • To propose remedial steps to prevent future public health casualties.

Main Methods:

  • Literature review and analysis of historical scientific advisory committee decisions.
  • Examination of the impact of the LNT model on radiation research.
  • Identification of systemic flaws in the application of science.

Main Results:

  • The unverified LNT model impeded the study of radiation hormesis for decades.
  • This obstruction likely resulted in over 15 million preventable cancer deaths globally.
  • Systemic deficiencies in scientific infrastructure were identified.

Conclusions:

  • Faith in unverified hypotheses, like the LNT model, stalls scientific progress and causes public health harm.
  • Correcting identified deficiencies in scientific infrastructure is crucial for accurate application of science.
  • Revisiting radiation protection policies based on robust scientific evidence is necessary.