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Related Experiment Video

Updated: Apr 28, 2026

Chemical Conjugation of a Purified DEC-205-Directed Antibody with Full-Length Protein for Targeting Mouse Dendritic Cells In Vitro and In Vivo

Chemical Conjugation of a Purified DEC-205-Directed Antibody with Full-Length Protein for Targeting Mouse Dendritic Cells In Vitro and In Vivo

Published on: February 5, 2021

Dendritic cell-targeted vaccines.

Lillian Cohn¹, Lélia Delamarre²

¹Laboratory of Molecular Immunology, Rockefeller University , New York, NY , USA.

Frontiers in Immunology

|June 10, 2014

Summary

Developing effective vaccines against intracellular pathogens and cancer remains difficult. This review explores strategies for enhancing T-cell responses by targeting dendritic cells (DCs) for improved antigen cross-presentation.

Keywords:

CD8+ T cells MHC class I adjuvants dendritic cells immunologic vaccination

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Published on: June 19, 2013

Area of Science:

Immunology
Vaccinology
Cellular Biology

Background:

Effective vaccines inducing robust T-cell responses against intracellular pathogens and cancer are challenging.
CD8(+) T-cell activation relies on dendritic cells (DCs) presenting internalized antigens via cross-presentation.
Current strategies involve direct antigen delivery to DCs using antibody-mediated targeting of DC receptors.

Purpose of the Study:

To review key considerations for designing DC-targeted vaccines.
To discuss factors influencing antigen cross-presentation by DCs.
To highlight the impact of DC subsets, intracellular trafficking, and maturation signals on vaccine efficacy.

Main Methods:

Review of existing literature on DC targeting and vaccine design.
Analysis of the mechanisms of antigen cross-presentation.
Discussion of DC subsets, antigen trafficking, and maturation signals.

Main Results:

DC-targeted antigen delivery is a promising vaccine strategy.
DC subset specialization impacts immune response outcomes.
Antigen intracellular trafficking and DC maturation signals critically influence cross-presentation efficacy.

Conclusions:

Optimizing DC-targeted vaccines requires understanding DC biology.
Tailoring antigen delivery and considering DC signals can enhance vaccine-induced T-cell immunity.
Further research into DC subsets and maturation is crucial for developing potent vaccines.