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Related Experiment Video

Updated: Apr 28, 2026

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

Published on: October 25, 2018

A new toolbox for assessing single cells.

Konstantinos Tsioris¹, Alexis J Torres, Thomas B Douce

¹Department of Chemical Engineering.

Annual Review of Chemical and Biomolecular Engineering

|June 10, 2014

Summary

New tools enable unprecedented single-cell biology studies, offering high resolution in genomics, transcriptomics, and proteomics. This review details methods for analyzing cellular responses to perturbations and interactions.

Keywords:

cell-cell interaction genomics microenvironment proteomics single-cell analysis soluble factors transcriptomics

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Last Updated: Apr 28, 2026

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

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Published on: October 25, 2018

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Analysis of Multidimensional Microscopy Data Using Cell-ACDC

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Published on: November 7, 2025

Area of Science:

Single-cell biology
Molecular biology
Biotechnology

Background:

Technological advancements allow unprecedented resolution in studying single cells.
Single-cell analysis is crucial for understanding complex biological systems.

Purpose of the Study:

To review advances in tools for single-cell analysis across genomics, transcriptomics, and proteomics.
To highlight methods for studying cellular responses to perturbations and interactions at the single-cell level.

Main Methods:

Examination of mature and nascent techniques for single-cell genomics, transcriptomics, and proteomics.
Overview of tools for analyzing biological responses to perturbations.
Description of methods for studying cell interactions and microenvironment influences.

Main Results:

A comprehensive toolbox of single-cell analysis techniques is presented.
Recent advances and opportunities for improvement in single-cell methodologies are discussed.
The review covers tools for analyzing cellular responses to soluble ligands, chemical ligands, microenvironment, and cell-cell interactions.

Conclusions:

The presented toolbox serves as a starting point for designing single-cell experiments.
Enhanced single-cell resolution facilitates deeper biological insights.
The review empowers researchers with advanced tools for dissecting cellular mechanisms.