Ionic liquids in pharmaceutical applications

Area of Science:

• Materials Science
• Pharmaceutical Science
• Green Chemistry

Background:

• Ionic liquids (ILs) are advanced materials with diverse applications, including energy technologies and carbon capture.
• Pharmaceutical compounds often suffer from low solubility and bioavailability, limiting their therapeutic efficacy.
• Drug polymorphism presents challenges in drug formulation and consistent therapeutic outcomes.

Purpose of the Study:

• To review the application of ionic liquid methodologies in addressing critical pharmaceutical challenges.
• To explore the potential of ILs as carriers for pharmaceutical active compounds.
• To highlight the synthesis of ILs for pharmaceutical applications.

Main Methods:

• Literature review of IL applications in pharmaceuticals.
• Analysis of IL properties for drug solubility enhancement.
• Investigation of IL-based strategies for polymorphism control.

Main Results:

• Ionic liquids can significantly improve the solubility and bioavailability of poorly soluble drugs.
• ILs offer a promising approach to manage and control drug polymorphism.
• Tailored ILs can be synthesized to fulfill specific pharmaceutical roles.

Conclusions:

• Ionic liquids represent a powerful tool for overcoming major pharmaceutical industry challenges.
• ILs enhance drug delivery and efficacy by improving solubility and managing polymorphism.
• The strategic design of ILs provides novel solutions for pharmaceutical development.