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Ionic liquids in pharmaceutical applications.

I M Marrucho1, L C Branco, L P N Rebelo

  • 1Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, 2780-157 Oeiras, Portugal; email: imarrucho@itqb.unl.pt , lrebelo@itqb.unl.pt.

Annual Review of Chemical and Biomolecular Engineering
|June 10, 2014
PubMed
Summary
This summary is machine-generated.

Ionic liquids (ILs) offer innovative solutions for pharmaceutical challenges like poor drug solubility and polymorphism. These versatile salts enhance drug bioavailability and efficacy, addressing key industry hurdles.

Keywords:
drug deliveryionic liquidspharmaceuticalssynthesis

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Area of Science:

  • Materials Science
  • Pharmaceutical Science
  • Green Chemistry

Background:

  • Ionic liquids (ILs) are advanced materials with diverse applications, including energy technologies and carbon capture.
  • Pharmaceutical compounds often suffer from low solubility and bioavailability, limiting their therapeutic efficacy.
  • Drug polymorphism presents challenges in drug formulation and consistent therapeutic outcomes.

Purpose of the Study:

  • To review the application of ionic liquid methodologies in addressing critical pharmaceutical challenges.
  • To explore the potential of ILs as carriers for pharmaceutical active compounds.
  • To highlight the synthesis of ILs for pharmaceutical applications.

Main Methods:

  • Literature review of IL applications in pharmaceuticals.
  • Analysis of IL properties for drug solubility enhancement.
  • Investigation of IL-based strategies for polymorphism control.

Main Results:

  • Ionic liquids can significantly improve the solubility and bioavailability of poorly soluble drugs.
  • ILs offer a promising approach to manage and control drug polymorphism.
  • Tailored ILs can be synthesized to fulfill specific pharmaceutical roles.

Conclusions:

  • Ionic liquids represent a powerful tool for overcoming major pharmaceutical industry challenges.
  • ILs enhance drug delivery and efficacy by improving solubility and managing polymorphism.
  • The strategic design of ILs provides novel solutions for pharmaceutical development.