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Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development
Published on: April 15, 2013
Thunberol, a new sterol from the Chinese brown alga Sargassum thunbergii
Wen-Fei He1, Li-Gong Yao, Hai-Li Liu
1a School of Pharmacy, Wenzhou Medical University , Wenzhou 325035 , China.
Abstract:
A new sterol, named thunberol (1), along with four known analogs, 24-ethylcholesta-4,24(28)-dien-3-one (2), stigmasta-5,28-dien-3β-ol (3), cholesta-5,14-dien-3β-ol (4), and cholesta-5,23-dien-3β,25-diol (5), were isolated from the brown alga Sargassum thunbergii collected from East China Sea. The structures of these metabolites were elucidated on the basis of detailed spectroscopic analysis and by comparison with the literature data. Thunberol (1) exhibited significant inhibitory activity against protein tyrosine phosphatase 1B, a potential drug target for the treatment of Type-II diabetes and obesity, with an IC50 value of 2.24 μg/ml.
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