Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Randomized Experiments01:13

Randomized Experiments

6.3K
The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
6.3K
Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs01:20

Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs

407
Bioequivalence experimental study designs are crucial methodologies used in evaluating and comparing the bioavailability of different drug products. These designs are categorized into various types: completely randomized, randomized block, repeated measures, cross and carry-over, and Latin square designs.Completely randomized designs involve randomly allocating treatments to all subjects participating in the experiment. This allocation is achieved by assigning unique random numbers to subjects...
407
Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs01:15

Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs

417
Bioequivalence experimental study designs play a pivotal role in testing the effectiveness of various treatments. Key among these are the repeated measures, cross-over, carry-over, and Latin square designs. In the repeated measures design, each subject receives all treatments, allowing for temporal comparisons. This type of design is useful in reducing variability but requires careful planning to avoid bias.The cross-over design, an economical method, involves sequential administration of...
417
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

627
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
627
Blinding01:11

Blinding

2.9K
Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
2.9K
Cochran's Q Test01:17

Cochran's Q Test

1.1K
Cochran's Q Test is a nonparametric statistical test used to determine if there are potential differences in the outcomes of three or more related groups on a binary (yes/no) or dichotomous outcome. It is essentially an extension of the McNemar Test, which is limited to two related samples - Cochran's Q test can handle three or more related samples, making it more versatile in scenarios where subjects are measured under multiple conditions. The test statistic follows a Chi-Square...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Developing a rehabilitation intervention for eating and drinking difficulties following stroke through co-design stakeholder workshops.

BMC health services research·2026
Same author

Outpatient paracentesis for Ovarian Hyperstimulation Syndrome: STOP-OHSS feasibility study and RCT Synopsis.

Health technology assessment (Winchester, England)·2026
Same author

Clear Conversations: a mixed methods evaluation of a verbal health literacy initiative for health service providers.

BMC health services research·2026
Same author

Men's Preferences for Exiting Abdominal Aortic Aneurysm Surveillance: A Deliberative Engagement Session Study.

Patient preference and adherence·2026
Same author

Updating the Good Reporting of a Mixed Methods Study (GRAMMS) Reporting Guidelines: Protocol for a Methodological Review and Modified Delphi Process.

JMIR research protocols·2026
Same author

What models of community palliative rehabilitation exist for adults in the United Kingdom? - a national cross-sectional survey.

BMC palliative care·2026
Same journal

Efficacy of transcranial direct current stimulation for post-stroke urinary incontinence: study protocol for a randomized controlled trial.

Trials·2026
Same journal

Compression therapies for the treatment of venous leg ulcers: a mixed method process evaluation in a randomised controlled trial, VenUS6.

Trials·2026
Same journal

Cheek acupuncture for enhancing postoperative recovery after endoscopic sinus surgery: study protocol for a pilot randomized controlled trial.

Trials·2026
Same journal

Methodological guidance for incorporating lived experience in the early stages of core outcome set development: a scoping review.

Trials·2026
Same journal

IMPACT-Introduction of Mycotic Prophylaxis At Cystectomy Trial: perioperative mycotic prophylaxis with fluconazole to reduce postoperative complications following cystectomy-study protocol for a national multi-center, double-blinded, placebo-controlled, randomized clinical trial.

Trials·2026
Same journal

Correction: The BrEasT cancer afTER-CARE (BETTER-CARE) programme to improve breast cancer follow-up: design and feasibility study results of a cluster-randomised complex intervention trial.

Trials·2026
See all related articles

Related Experiment Video

Updated: Apr 28, 2026

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
04:53

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

10.1K

Getting added value from using qualitative research with randomized controlled trials: a qualitative interview study.

Alicia O'Cathain1, Jackie Goode, Sarah J Drabble

  • 1Health Services Research, Medical Care Research Unit, School of Health and Related Research (ScHARR), University of Sheffield, Regent Street, Sheffield S1 4DA, UK. a.ocathain@sheffield.ac.uk.

Trials
|June 11, 2014
PubMed
Summary
This summary is machine-generated.

Qualitative research integrated into health trials enhances evidence utility. For maximum impact, qualitative research must be viewed as essential and adequately resourced within the trial design.

More Related Videos

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
08:36

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

1.4K

Related Experiment Videos

Last Updated: Apr 28, 2026

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
04:53

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

10.1K
Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
08:36

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

1.4K

Area of Science:

  • Health Services Research
  • Qualitative Research Methods
  • Clinical Trial Design

Background:

  • Qualitative research is increasingly combined with randomized controlled trials in health interventions.
  • Understanding the perceived added value of qualitative research within trials is crucial for optimizing its application.

Purpose of the Study:

  • To explore researchers' perceptions of the added value of qualitative research when integrated into health intervention trials.

Main Methods:

  • A qualitative study involving semi-structured telephone interviews with 18 researchers experienced in conducting trials and/or qualitative research.
  • Analysis of interview data to identify themes and models of integration.

Main Results:

  • Researchers reported that qualitative research solved pretrial problems, explained trial findings, and increased evidence utility.
  • Three models of integration were identified: peripheral, add-on, and integral.
  • The 'integral-in-practice' model, where qualitative research was planned from the outset and adequately resourced, was associated with greater added value, though challenges in publishing this research limited its visibility.

Conclusions:

  • Combining qualitative research and trials strengthens evaluative research in health.
  • Effective integration requires viewing qualitative research as essential and ensuring it is properly resourced throughout the trial process to maximize its added value.