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Related Concept Videos

Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

1.5K
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
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Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

19
Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
19
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

40
The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
40
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

903
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
903
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

25
Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80%...
25
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

1.2K
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
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Related Experiment Video

Updated: Apr 28, 2026

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
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Acute pancreatitis: the stress factor.

Marcelo G Binker1, Laura I Cosen-Binker1

  • 1Marcelo G Binker, Laura I Cosen-Binker, CBRHC Research Center, 1053 Ciudad Autónoma de Buenos Aires, Buenos Aires 1426, Argentina.

World Journal of Gastroenterology
|June 11, 2014
PubMed
Summary

Acute pancreatitis, an inflammatory pancreatic disorder, can be worsened by chronic stress. Prior acute stress may decrease pancreatitis severity, but chronic stress effects need more research.

Keywords:
Acute stressChronic stressHeat shock proteinsPancreatitisTumor necrosis factor alpha

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Area of Science:

  • Gastroenterology
  • Pathophysiology
  • Endocrinology

Background:

  • Acute pancreatitis is a severe pancreatic inflammatory condition with varied causes, including gallstones and alcohol.
  • Pathophysiological events involve acinar cell dysfunction, protease activation, and inflammatory mediator release.
  • Severe cases can lead to systemic inflammatory response syndrome and multiorgan dysfunction syndrome.

Purpose of the Study:

  • To review the influence of acute-short-term and chronic stress on acute pancreatitis.
  • To highlight the under-researched impact of chronic stress on the exocrine pancreas.

Main Methods:

  • Literature review focusing on stress and acute pancreatitis.
  • Analysis of studies investigating acute-short-term stress effects.
  • Examination of research on chronic stress and pancreatic function.

Main Results:

  • Previous acute-short-term stress has been shown to decrease the severity of experimentally induced pancreatitis.
  • The detrimental effects of chronic stress on the exocrine pancreas are less understood and require further investigation.

Conclusions:

  • The timing and duration of stress significantly influence outcomes in acute pancreatitis.
  • Further research is needed to elucidate the mechanisms by which chronic stress exacerbates acute pancreatitis.