Another look at the association between diabetes and keratoconus
Mustafa Kosker1, Kunal Suri, Kristin M Hammersmith
1Cornea Service, Wills Eye Hospital, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA.
Cornea
|June 11, 2014
Summary
This study found a link between type 2 diabetes mellitus and keratoconus. Diabetic patients had a higher prevalence and severity of keratoconus, suggesting a potential association.
Area of Science:
- Ophthalmology
- Endocrinology
- Public Health
Background:
- Keratoconus is a progressive eye condition.
- Diabetes mellitus is a metabolic disorder with systemic implications.
- Understanding potential links between these conditions is crucial for patient care.
Purpose of the Study:
- To investigate the association between diabetes mellitus (DM) and keratoconus.
- To compare DM prevalence in keratoconus patients versus controls.
- To assess keratoconus severity in diabetic versus non-diabetic patients.
Main Methods:
- Two substudies were conducted: a retrospective prevalence comparison and a cross-sectional severity analysis.
- Data from 1377 keratoconus patients and 4131 controls were analyzed for prevalence.
- Keratoconus severity was evaluated in 75 type 2 diabetic and 225 non-diabetic keratoconus patients.
Main Results:
- Type 1 DM prevalence was similar between groups.
- Type 2 DM prevalence was significantly higher in keratoconus patients (6.75%) compared to controls (4.84%).
- Diabetic patients with keratoconus showed a higher risk of severe keratoconus (OR=2.691).
Conclusions:
- A positive association exists between type 2 diabetes mellitus and the presence of keratoconus.
- Type 2 DM may also be linked to increased severity of keratoconus.
- Further research is warranted to elucidate the underlying mechanisms of this association.
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