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Related Experiment Video

Updated: Apr 28, 2026

A Mouse Model to Evaluate the Long-Term Structural and Functional Outcomes after the Reversal of Prolonged Unilateral Ureteric Obstruction

A Mouse Model to Evaluate the Long-Term Structural and Functional Outcomes after the Reversal of Prolonged Unilateral Ureteric Obstruction

Published on: July 18, 2025

Do multiple ureteroscopies alter long-term renal function? A study using estimated glomerular filtration rate.

Brian C Sninsky¹, R Allan Jhagroo, Brad C Astor

¹1 Department of Urology, University of Wisconsin School of Medicine and Public Health , Madison, Wisconsin.

Journal of Endourology

|June 11, 2014

Summary

This summary is machine-generated.

Multiple ureteroscopies (URS) for kidney stones do not harm long-term kidney function in patients with pre-existing kidney disease. This study found no negative impact on estimated glomerular filtration rate (eGFR) after URS procedures.

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Area of Science:

Nephrology
Urology

Background:

Ureteroscopy (URS) with laser lithotripsy is standard for symptomatic urolithiasis.
Limited data exist on the long-term renal function effects of multiple URS procedures, especially in patients with pre-existing kidney disease.

Purpose of the Study:

To investigate the impact of multiple ureteroscopies (URS) on long-term renal function in patients with mild to moderate kidney disease.
To address limitations of previous studies using acute obstruction eGFR estimates and including other stone treatment histories.

Main Methods:

Retrospective chart review of patients with baseline eGFR < 90 mL/min/1.73 m² undergoing at least two URS for nephrolithiasis (2004-2012).
Exclusion of patients with any history of shockwave lithotripsy (SWL) or percutaneous nephrolithotomy (PCNL).
Recorded baseline and follow-up eGFR, stone location, total stone burden, and comorbidities.

Main Results:

Mean eGFR increased from 68.0 to 75.4 mL/min/1.73 m² (10.1% mean increase) over a mean follow-up of 28.1 months.
No significant difference in eGFR change was observed based on stone location (kidney alone vs. ureter and kidney).
Age, diabetes, hypertension, baseline creatinine, stone burden, and number of URS were not significantly associated with eGFR change.

Conclusions:

Multiple ureteroscopies for kidney stones appear safe for long-term renal function in patients with stage 2-3 chronic kidney disease.
eGFR measured prior to acute stone presentation is a reliable baseline for assessing treatment impact.