Related Experiment Video
Updated: Feb 17, 2026
08:12
Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation
Published on: July 15, 2015
19.9K
Changes by Era in Risk Factors and Outcomes Among Deceased Donor Kidney Transplant Recipients With Delayed Graft
Camille C Ylagan1, Paul E Schindler1, Dave B Patel1
1Division of Nephrology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Clinical Transplantation
|February 15, 2026
Summary
Delayed graft function (DGF) in deceased donor kidney transplants has evolving risk factors. Recent eras show improved outcomes, particularly reduced acute rejection, suggesting better management strategies for kidney transplant recipients.
Area of Science:
- Nephrology
- Transplantation Surgery
- Immunology
Background:
- Delayed graft function (DGF) is a significant complication in deceased donor kidney transplant recipients (DDKTRs).
- Currently, no effective therapeutic agents exist for preventing or treating DGF.
- Predicting DGF and its associated outcomes relies on donor and recipient factors, which may change over time.
Purpose of the Study:
- To analyze the temporal trends in risk factors for DGF.
- To evaluate changes in DGF incidence and associated outcomes over different eras.
- To assess the impact of evolving medical practices on DGF and kidney transplant success.
Main Methods:
- Deceased donor kidney transplant recipients (DDKTRs) were categorized into four eras based on transplant year (2000-2005, 2006-2011, 2012-2017, 2018-2021).
- Risk factors for DGF, one-year graft failure (uncensored and death-censored), death with a functioning graft, and acute rejection were analyzed by era.
- Statistical analysis was performed to identify significant associations within and across eras.
Main Results:
- The incidence of DGF varied significantly across the four eras.
- Recent eras demonstrated a shorter duration of DGF and lower median dialysis counts.
- Donation after circulatory death, higher donor creatinine, and longer pre-transplant dialysis were DGF risk factors, while preemptive transplant was protective.
- Acute rejection risk substantially decreased in later eras (E3 and E4) compared to the earliest era (E1).
- Trends indicated reduced risks for uncensored graft failure and death with a functioning graft in more recent eras.
Conclusions:
- Risk factors for DGF have shown both consistent and changing patterns over time.
- Improved management strategies have likely contributed to the observed reduction in acute rejection among DGF patients in recent eras.
- Recent transplant eras show promising trends towards improved graft survival and patient survival post-kidney transplantation.
Related Concept Videos
01:28Kidney Transplant I: Introduction
514
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
514
01:26Kidney Transplant II: Surgical Procedure
462
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
462
01:16Kidney Transplant III: Nursing Management
417
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
417
01:24Tissue Transplantation
1.1K
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
1.1K
01:29Acute Kidney Injury III: Clinical Manifestations
993
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
993