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Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
Published on: April 3, 2017
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Mutual interaction between iron homeostasis and obesity pathogenesis
Alexandr A Nikonorov1, Margarita G Skalnaya2, Alexey A Tinkov1
1Department of Biochemistry, Orenburg State Medical Academy, Sovetskaya Street 6, Orenburg 460000, Russia.
Summary
Obesity is linked to iron deficiency and altered iron balance. Iron overload in adipose tissue can worsen obesity through oxidative stress and inflammation, suggesting a mutual relationship.
Area of Science:
- Metabolic disorders
- Nutritional science
- Pathophysiology
Background:
- Obesity is a significant global health issue.
- Systemic iron deficiency and hypoferremia are common in obesity.
- Emerging evidence suggests a causal link between iron status and obesity-related diseases.
Purpose of the Study:
- To explore the bidirectional relationship between iron homeostasis and obesity.
- To elucidate mechanisms causing iron imbalance in obesity.
- To investigate iron's role in the pathogenesis of obesity-related conditions.
Main Methods:
- Literature review and synthesis of existing research on iron metabolism and obesity.
- Analysis of proposed mechanisms for hypoferremia in obese individuals.
- Examination of iron's impact on adipose tissue function and inflammation.
Main Results:
- Obesity-induced inflammation and hyperproduction of hepcidin and lipocalin 2 contribute to hypoferremia.
- Iron sequestration in the reticuloendothelial system increases adipose tissue iron content.
- Iron overload in adipose tissue promotes oxidative stress, ER stress, and endocrine dysfunction, potentially exacerbating obesity.
Conclusions:
- A complex interplay exists between disturbed iron homeostasis and obesity pathogenesis.
- Iron-mediated toxicity in adipose tissue may contribute to obesity progression.
- Targeting iron dysregulation is a potential therapeutic strategy for obesity and its complications.
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