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Updated: Jul 1, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
A novel silver(I) coordination compound with diphenyl((8-oxyquinolyl)methyl)phosphine oxide. Synthesis, Structure,
Alina Sivolap1, Vladimir Baulin2, Dmitriy Baulin1
1Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, 31-4, Leninsky prospect, Moscow 119071, Russia.
None:
As part of the search for new organic ligands capable of effectively binding rare and biologically active metals - potential components of novel functional materials and medical agents for diagnostic and therapeutic purposes a new complex of diphenyl((8-oxyquinolyl)methyl)phosphine oxide (L) with silver, [AgNO3L]2, was synthesized. Its composition and structure were determined based on a combination of elemental analysis, SC-XRD analysis, and IR spectroscopy data. The complex adopts a dimeric structure sustained by double bridging coordination of the phosphoryl oxygen atoms to two silver(I) ions. In the crystal lattice, these dimers associate via π-π interactions between the quinoline rings, generating infinite chains along the crystallographic axis. The thermal stability parameters of [AgNO3L]2 were determined by thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). The in vitro anticancer activity of [AgNO3L]2 was evaluated against four human cancer cell lines (A549, MCF-7, SH-SY5Y, HeLa). It was established that the [AgNO3L]2 complex significantly outperforms cisplatin in terms of cytotoxic activity. Further studies showed that [AgNO3L]2 exhibits antioxidant activity, inhibits lipid peroxidation, and reduces intracellular ROS levels after exposure to hydrogen peroxide.
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