Sinonasal glomangiopericytoma causing oncogenic osteomalacia

Area of Science:

• Endocrinology
• Oncology
• Orthopedics
• Pathology

Background:

• Recurrent femur neck fractures can indicate underlying metabolic bone diseases.
• Oncogenic osteomalacia is a rare paraneoplastic syndrome characterized by renal phosphate wasting.
• Sinonasal tumors are uncommon, and their association with metabolic disorders is even rarer.

Purpose of the Study:

• To report a unique case of oncogenic osteomalacia secondary to a sinonasal glomangiopericytoma.
• To highlight the diagnostic challenges and clinical presentation of this rare condition.
• To emphasize the importance of considering rare tumors in the differential diagnosis of metabolic bone disease.

Main Methods:

• Clinical case presentation of a 60-year-old woman with recurrent femur fractures.
• Laboratory investigations including serum calcium, phosphate, alkaline phosphatase, and parathyroid hormone levels.
• Radiological examinations to identify the primary tumor.
• Histopathological analysis of the resected sinonasal mass.
• Postoperative monitoring of clinical and laboratory parameters.

Main Results:

• The patient presented with hypophosphatemia and elevated alkaline phosphatase, suggestive of osteomalacia.
• A glomangiopericytoma was identified in the maxillary alveolar bone and nasal cavity.
• Post-tumor resection, the patient's laboratory values showed significant improvement, indicating resolution of oncogenic osteomalacia.

Conclusions:

• Sinonasal glomangiopericytoma can manifest as oncogenic osteomalacia, causing significant skeletal complications.
• Surgical excision of the causative tumor is an effective treatment for oncogenic osteomalacia.
• This case underscores the necessity of a comprehensive diagnostic approach for unexplained metabolic bone disorders.