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Updated: Apr 28, 2026

Anti-Nuclear Antibody Screening Using HEp-2 Cells
Published on: June 23, 2014
Reply to: Hemichorea Associated with CASPR2 Antibody
Ritesh A Ramdhani1, Steven J Frucht1
1Movement Disorders Division, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
This study discusses hemichorea linked to the CASPR2 antibody, responding to previous research on LGI1 antibody-associated chorea. It highlights the importance of antibody testing in movement disorder diagnosis.
Area of Science:
- Neurology
- Immunology
Background:
- Autoimmune encephalitis can present with movement disorders.
- Antibodies targeting neuronal surface proteins, such as CASPR2 and LGI1, are implicated.
Purpose of the Study:
- To discuss hemichorea associated with CASPR2 antibody.
- To provide a response to existing literature on LGI1 antibody-associated chorea.
Main Methods:
- Literature review and case discussion.
- Analysis of antibody-mediated neurological disorders.
Main Results:
- CASPR2 antibody-associated hemichorea is a recognized neurological manifestation.
- Distinguishing between different antibody profiles is crucial for diagnosis.
Conclusions:
- Antibody testing is essential for diagnosing autoimmune movement disorders.
- Understanding the spectrum of CASPR2 and LGI1 antibody-related conditions improves patient care.
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