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Updated: Apr 28, 2026
Ileectomy-induced Bile Overaccumulation in Mouse Intestine
Published on: August 21, 2017
Morphological changes in the liver and kidneys of rats subjected to terminal ileum exclusion during obstructive
Evandro Luis de Oliveira Costa1, Geraldo Magela de Azevedo2, Andy Petroianu3
1Department of Surgery, Faculty of Medicine, Minas Gerais Federal University, Belo Horizonte, MG, Brazil.
Purpose:
To investigate the effects of ileal exclusion on hepatic and renal morphology in extra-hepatic cholestasis.
Methods:
Twenty four rats were distributed into three groups. Group 1 (control) underwent laparotomy and laparorrhaphy. The animals in groups 2 and 3 underwent hepatic duct ligature and kept in cholestasis for four weeks. After this period, the rats in groups 2 and 3 underwent internal biliary derivation. In Group 3, the last ten centimeters of the terminal ileum were by passed and excluded. Four weeks later, histological and biochemical analysis were performed in all animals of the three groups.
Results:
In Group 1, no abnormalities regarding hepatic morphology were observed. All animals from groups 2 and 3 presented hepatic fibrosis. No difference was observed between the two groups. No morphological differences in renal histology could be identified among the three groups. There were differences in AST (p<0.05), ALT (p<0.05), direct bilirubin (p<0.05), ƔGT (p<0.05), urea (p<0.05) and creatinine (p<0.05) in Group 3 compared to control.
Conclusion:
The distal ileum exclusion had no influence upon the hepatic and renal morphological alterations, and biochemical liver and kidney tests have worsened.
