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Updated: Apr 28, 2026

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Published on: February 28, 2012
Oral anticoagulation and vitamin K deficiency
1Prof. Dr. Sabine Eichinger-Hasenauer, Dept. of Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Wien, Austria,
Abstract:
A 61-year old woman with atrial fibrillation developed macrohaematuria during anticoagulant treatment with a direct oral factor Xa inhibitor for stroke prevention. Abnormal results of coagulation assays were first interpreted as an effect of the anticoagulant. However, upon further testing diagnosis of vitamin K deficiency was established. After vitamin K supplementation, coagulation tests normalized and macrohaematuria disappeared. Treatment with broad spectrum antibiotics for urinary tract infection was finally established as a rare cause for vitamin K deficiency in the patient.
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