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Related Experiment Video

Updated: Apr 28, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Systemic lupus erythematosus complicating simple silicosis.

C D Lucas1, N Amft2, P T Reid3

  • 1Department of Respiratory Medicine, University of Edinburgh, Edinburgh EH16 4TJ, UK, clucas@staffmail.ed.ac.uk.

Occupational Medicine (Oxford, England)
|June 13, 2014
PubMed
Summary

Occupational silica exposure can cause silicosis, a lung disease linked to autoimmune conditions like systemic lupus erythematosus (SLE). Even simple silicosis may increase SLE risk, especially in men, highlighting the importance of occupational history.

Keywords:
Autoimmunitysilicasilicosissystemic lupus erythematosus.

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Area of Science:

  • Occupational medicine
  • Rheumatology
  • Pulmonology

Background:

  • Silicosis, an irreversible lung disease from crystalline silica inhalation, is linked to autoimmune complications.
  • The association between silicosis and systemic lupus erythematosus (SLE) is primarily recognized in acute or accelerated forms.

Observation:

  • A case of SLE, typically affecting young females, developed in a male former stonemason with simple silicosis.
  • This presentation challenges the typical demographic and disease severity associated with SLE and silicosis.

Findings:

  • Occupational silica exposure, even in simple silicosis, is linked to the development of systemic lupus erythematosus (SLE).
  • This case and literature review suggest a broader association between silica exposure and autoimmune diseases than previously recognized.

Implications:

  • Emphasizes the critical importance of obtaining a detailed occupational history in patients presenting with SLE, particularly in males.
  • Suggests that simple silicosis may be an underrecognized risk factor for developing autoimmune diseases like SLE.
  • Highlights the need for further research into the mechanisms linking silica exposure to autoimmunity.