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Antioxidant status in blood of obese children: the relation between trace elements, paraoxonase, and arylesterase

Yasemin Cayir1, Atilla Cayir, Mehmet Ibrahim Turan

  • 1Faculty of Medicine, Department of Family Medicine, Ataturk University, Erzurum, Turkey.

Biological Trace Element Research
|June 13, 2014
PubMed

Insights

Obese children show lower antioxidant markers, paraoxonase (PON1) and arylesterase (ARE). Selenium (Se) levels positively correlate with PON1, suggesting a link between selenium and antioxidant systems in pediatric obesity.

Area of Science:

  • Pediatric Endocrinology
  • Nutritional Biochemistry
  • Oxidative Stress Research

Background:

  • Obesity is linked to systemic complications driven by chronic inflammation and oxidative stress.
  • Nutritional deficiencies, including trace element imbalances, can occur in obese children.
  • Paraoxonase (PON1) and arylesterase (ARE) are key indicators of the body's oxidant-antioxidant status.

Purpose of the Study:

  • To investigate the relationship between serum paraoxonase (PON1) and arylesterase (ARE) levels and serum concentrations of trace elements (zinc, copper, manganese, selenium) in obese children.
  • To explore the role of trace elements in the oxidant-antioxidant balance in pediatric obesity.

Main Methods:

  • Comparative analysis of 57 obese children (aged 6-17) and 48 healthy controls.
  • Measurement of serum PON1 and ARE activity.
  • Quantification of serum trace elements (Zn, Cu, Mn, Se) and various biochemical markers (lipids, glucose, liver enzymes).

Main Results:

  • Obese children exhibited significantly lower serum PON1 and ARE activity compared to healthy controls (P < 0.05).
  • Significant differences in serum copper, zinc, manganese, and selenium levels were observed between obese and control groups (P < 0.05).
  • A significant positive correlation was found between serum selenium (Se) and PON1 levels in obese children (P < 0.05, r = 0.31).

Conclusions:

  • Obesity in children is associated with reduced antioxidant enzyme activity (PON1, ARE).
  • Trace element levels, particularly selenium, may play a role in modulating antioxidant capacity in obese children.
  • The positive correlation between selenium and PON1 suggests a potential therapeutic target for managing oxidative stress in pediatric obesity.

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