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Functional evolution of PLP-dependent enzymes based on active-site structural similarities

Jonathan Catazaro1, Adam Caprez, Ashu Guru

  • 1Department of Chemistry, University of Nebraska-Lincoln, Lincoln, Nebraska, 68588-0304.

Proteins
|June 13, 2014
PubMed
Summary

Active site structures reveal evolutionary relationships in enzyme families. This method aids in functional annotation for distantly related proteins, overcoming low sequence identity challenges.

Keywords:
CPASSPLP-dependent enzymesfunctional evolutionligand binding sites

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