Novel endocuff-assisted colonoscopy significantly increases the polyp detection rate: a randomized controlled trial

Area of Science:

• Gastroenterology
• Endoscopy
• Colorectal Cancer Screening

Background:

• Screening colonoscopy is vital for reducing colorectal cancer mortality.
• The Endocuff (EC) is a novel attachment designed to enhance colonoscope performance.
• Evaluating the efficacy of new endoscopic tools is crucial for improving cancer detection.

Purpose of the Study:

• To compare the polyp detection rates of standard colonoscopy versus Endocuff-assisted colonoscopy.
• To assess the impact of the Endocuff on the number and distribution of detected polyps.
• To determine the safety and feasibility of using the Endocuff in a clinical setting.

Main Methods:

• A prospective, randomized, 2-center trial involving 498 patients undergoing screening colonoscopy.
• Patients were randomized to undergo standard colonoscopy or colonoscopy with the Endocuff attachment.
• Key outcome measures included overall polyp detection rate, number of polyps per patient, and polyp distribution.

Main Results:

• The Endocuff group showed a 63% higher number of polyps per patient (2.00 vs. 1.00, P<0.0001).
• Polyp detection rate increased by 14% in the Endocuff group (56% vs. 42%, P=0.001).
• Adenoma detection per patient increased by 86% (P=0.002), with significant improvements in the sigmoid and cecum for smaller polyps.

Conclusions:

• Endocuff-assisted colonoscopy is safe and feasible, significantly increasing polyp and adenoma detection rates.
• The Endocuff shows particular efficacy in detecting polyps in the sigmoid colon.
• This device holds potential for enhancing the accuracy of colorectal cancer screening colonoscopies.