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Related Experiment Video

Updated: Apr 28, 2026

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
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Non-reactive mood in outpatient depression: A 557-case study.

F Benazzi

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    |June 13, 2014
    PubMed
    Summary

    Non-reactive mood is uncommon in major depressive episode (MDE) outpatients, affecting 12% of individuals. This mood presentation is linked to more severe depression, with no significant differences between unipolar and bipolar II patients.

    Area of Science:

    • Psychiatry
    • Clinical Psychology

    Background:

    • Major Depressive Episode (MDE) is a common psychiatric condition.
    • Understanding mood reactivity in MDE is crucial for effective treatment.
    • Non-reactive mood is a less understood subtype of MDE.

    Purpose of the Study:

    • To determine the prevalence of non-reactive mood in outpatients with MDE.
    • To compare the characteristics of patients with non-reactive versus reactive mood.

    Main Methods:

    • A cohort of 557 consecutive unipolar and bipolar II outpatients with MDE were assessed.
    • Utilized Structured Clinical Interview for DSM-IV, MADRS, and GAF scales for evaluation.
    • Non-reactive mood was specifically assessed using the MADRS.

    Main Results:

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    • Non-reactive mood was identified in 12.0% of the MDE outpatient sample.
    • Patients with non-reactive mood exhibited significantly greater MDE severity.
    • No significant differences in age, gender, or diagnostic subtype (unipolar vs. bipolar II) were found between mood reactivity groups.

    Conclusions:

    • Non-reactive mood is relatively uncommon in unipolar and bipolar II depressed outpatients.
    • Non-reactive mood in MDE is associated with increased depression severity.
    • The distribution of unipolar and bipolar II patients does not differ between non-reactive and reactive mood groups.