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Updated: Apr 28, 2026
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Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
Published on: July 16, 2014
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Pallidal stimulation in Parkinson's disease does not induce apathy
Summary
Internal globus pallidus deep brain stimulation did not worsen apathy, depression, or anxiety in Parkinson's disease patients. Psychiatric and cognitive scores remained stable post-surgery.
Area of Science:
- Neurology
- Neurosurgery
- Psychiatry
Background:
- Apathy is a known side effect of subthalamic nucleus deep brain stimulation for Parkinson's disease.
- Limited research exists on psychiatric outcomes following internal globus pallidus deep brain stimulation.
Purpose of the Study:
- To investigate the psychiatric and cognitive effects of internal globus pallidus deep brain stimulation in Parkinson's disease patients.
- To assess changes in apathy, depression, and anxiety levels after pallidal stimulation.
Main Methods:
- Twenty Parkinson's disease patients undergoing bilateral pallidal stimulation were evaluated.
- Psychiatric, neuropsychological, and motor assessments were conducted pre-surgery and at 3 and 6 months post-surgery.
- Standardized scales were used to measure apathy, depression, and anxiety.
Main Results:
- Apathy scores remained stable from pre-surgery to 6 months post-surgery.
- No significant differences were observed in depression or anxiety scores between preoperative and postoperative assessments.
- Cognitive function, assessed by the Mattis Dementia Rating Scale, also remained stable.
Conclusions:
- Internal globus pallidus deep brain stimulation does not appear to negatively impact psychiatric or cognitive status in Parkinson's disease patients.
- Pallidal stimulation is a safe option regarding mental health outcomes in this patient population.
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