The association between sleep characteristics and prothrombotic markers in a population-based sample: Chicago Area...

Area of Science:

• Cardiovascular Research
• Sleep Medicine
• Hematology

Background:

• Short sleep duration and poor sleep quality are linked to coronary heart disease (CHD) mortality.
• The exact pathophysiologic mechanisms connecting sleep disturbances to CHD remain unclear.
• Sleep apnea may confound this association due to its link with thrombus formation.

Purpose of the Study:

• To investigate the association between sleep duration and quality with prothrombotic biomarkers.
• To examine these associations in adults with a low probability of sleep apnea.

Main Methods:

• Included 506 adults aged 35-64 with an apnea-hypopnea index <15.
• Assessed sleep duration and maintenance using 7-day wrist actigraphy.
• Measured Factor VIII (FVIII), von Willebrand factor (vWF), thrombin antithrombin (TAT) complexes, and plasminogen activator inhibitor-1 (PAI-1).

Main Results:

• Sleep duration, maintenance, and daytime sleepiness were not associated with FVIII, vWF, or TAT.
• Sleep maintenance showed a modest inverse association with higher PAI-1 levels after adjustments.

Conclusions:

• Mild sleep impairment is modestly associated with coagulation activation.
• Further research is needed to explore the role of fibrinolytic factors in sleep-mediated coronary thrombosis.