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Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

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Overview
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Asthma I: Introduction01:28

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Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
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Microbiota of the Respiratory Tract01:29

Microbiota of the Respiratory Tract

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The human respiratory tract, comprising the upper and lower segments, serves as a critical interface with the external environment. The upper respiratory tract (URT)—including the nostrils, sinuses, pharynx, and oropharynx—is heavily colonized by microbes, while the lower respiratory tract (LRT), composed of the larynx, trachea, bronchi, and lungs, was long thought to be sterile. However, recent molecular studies have revealed that the lungs are not devoid of microbes but act more...
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Asthma-I: Introduction01:29

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Related Experiment Video

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Murine Model of Allergen Induced Asthma
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Mammalian airborne allergens.

Rob C Aalberse1

  • 1Sanquin Blood Supply Foundation and Academic Medical Centre, Amsterdam, The Netherlands.

Chemical Immunology and Allergy
|June 14, 2014
PubMed
Summary

Indoor airborne mammalian allergens, primarily from lipocalins and secretoglobins, cause most allergic symptoms today. Identifying and quantifying these indoor allergens remains a complex proteomic challenge.

Area of Science:

  • Immunology
  • Proteomics
  • Environmental Health

Background:

  • Mammalian allergens are a significant cause of indoor allergies.
  • Historically, horse dandruff was a key allergen source, but indoor exposure is now dominant.
  • House dust allergens have been linked to mites and lysine-sugar conjugates.

Purpose of the Study:

  • To discuss the relevance of mammalian allergens in house dust.
  • To review the protein families involved in allergic reactions to airborne dust.
  • To highlight the challenges in characterizing indoor airborne allergens.

Main Methods:

  • Literature review on mammalian allergens and house dust.
  • Analysis of protein families contributing to allergic reactions.
  • Discussion of proteomic challenges in allergen identification.

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Main Results:

  • Mammalian allergens are mainly from lipocalins and secretoglobins (e.g., Fel d 1-like proteins).
  • Serum albumins, cystatins, and latherins play a minor role.
  • Complex protein family relationships and post-translational modifications complicate allergen characterization.

Conclusions:

  • Lipocalins and secretoglobins are key indoor airborne mammalian allergens.
  • Accurate qualitative and quantitative description of these allergens is a significant proteomic challenge.
  • Further research is needed to fully understand and manage indoor allergen exposure.