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Decreased motor function is associated with poorer cognitive function in elderly with type 2 diabetes
Elizabeth Guerrero-Berroa1, Ramit Ravona-Springer2, Anthony Heymann3
1Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, N.Y., USA.
Dementia and Geriatric Cognitive Disorders Extra
|June 14, 2014
Summary
In older adults with type 2 diabetes (T2D), poorer motor function like slower walking and weaker grip strength correlates with cognitive decline in most areas. Episodic memory was not associated, suggesting different underlying mechanisms.
Area of Science:
- Gerontology
- Neuroscience
- Endocrinology
Background:
- Impaired motor function is linked to cognitive decline and dementia.
- The relationship between motor function and cognition in elderly individuals with type 2 diabetes (T2D) is not well understood.
- This study focuses on a large cohort of cognitively normal elderly individuals with T2D.
Purpose of the Study:
- To investigate the association between motor function and various cognitive domains in elderly individuals with T2D.
- To determine if motor impairments predict cognitive deficits in this population.
- To explore potential differences in these associations compared to non-T2D populations.
Main Methods:
- Cross-sectional study design.
- Hierarchical linear regressions used to analyze data.
- Assessed three motor measures: timed walk, grip strength, and self-reported motor difficulties.
- Evaluated correlations with episodic memory, attention/working memory, semantic categorization, executive function, and overall cognition, controlling for demographics.
Main Results:
- Longer timed walk (slower gait speed) was associated with poorer performance across multiple cognitive domains.
- Weaker grip strength was also linked to deficits in most cognitive areas assessed.
- Episodic memory performance did not show a significant association with the motor function measures.
Conclusions:
- Motor and cognitive function associations in individuals with T2D are consistent with findings in non-T2D populations.
- The lack of association between motor function and episodic memory may indicate distinct underlying pathological mechanisms, potentially not related to Alzheimer's disease.
- Motor function assessment could offer insights into broader cognitive health in elderly individuals with T2D.
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