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Related Concept Videos

Overview of Cell Death01:30

Overview of Cell Death

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Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
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Meiosis vs. Mitosis02:57

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Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
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DNA Damage can Stall the Cell Cycle02:36

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In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
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In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
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Cell death is the irreversible loss of cellular structure and function, representing the final stage of severe injury. It plays a key role in both normal physiology and disease.Types of Cell DeathThe two main types are necrosis and apoptosis, though others like necroptosis and pyroptosis also exist.Necrosis:Necrosis is an unregulated form of cell death caused by severe injury such as trauma, toxins, or ischemia. It is characterized by cell swelling, membrane loss, rupture, and leakage of...
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Updated: Apr 28, 2026

Cell Death Associated with Abnormal Mitosis Observed by Confocal Imaging in Live Cancer Cells
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Cell Death Associated with Abnormal Mitosis Observed by Confocal Imaging in Live Cancer Cells

Published on: August 21, 2013

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Stressing mitosis to death.

Andrew Burgess1, Mina Rasouli2, Samuel Rogers2

  • 1The Kinghorn Cancer Centre, Garvan Institute of Medical Research , Sydney, NSW , Australia ; St. Vincent's Clinical School, Faculty of Medicine, UNSW Australia , Sydney, NSW , Australia.

Frontiers in Oncology
|June 14, 2014
PubMed
Summary
This summary is machine-generated.

Cellular stress during mitosis can cause cell cycle arrest or premature exit, impacting genomic stability. Understanding these stress responses is crucial for improving cancer chemotherapy effectiveness.

Keywords:
Cdk1DNA damageSACcheckpointkinetochoremetaphasemitosisspindle

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Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations
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Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations

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Area of Science:

  • Cell Biology
  • Genetics
  • Cancer Research

Background:

  • Mitosis is the final stage of cell division, involving genome segregation.
  • The spindle assembly checkpoint (SAC) ensures correct chromosome attachment to microtubules.
  • DNA damage during mitosis typically leads to cell death to maintain genomic stability.

Purpose of the Study:

  • To review the effects of common cellular stresses on mitosis.
  • To examine how these stresses influence the efficacy of mitotic chemotherapies.

Main Methods:

  • Literature review of stress responses during mitosis.
  • Analysis of SAC function under stress.
  • Evaluation of mitotic exit pathways.

Main Results:

  • Stress can induce mitotic arrest or premature mitotic exit.
  • Incomplete spindle attachment triggers the SAC, prolonging mitosis.
  • Some stresses promote mitotic exit, bypassing cell death pathways.

Conclusions:

  • Cellular stresses significantly impact mitotic progression and cell fate.
  • Altered mitotic dynamics under stress may affect chemotherapy outcomes.
  • Further research is needed to optimize cancer treatments based on stress responses.