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Published on: August 31, 2013
Forward genetic approaches for elucidation of novel regulators of Lyme arthritis severity
Kenneth K C Bramwell1, Cory Teuscher2, Janis J Weis1
1Department of Pathology, University of Utah Salt Lake City, UT, USA.
Abstract:
Patients experiencing natural infection with Borrelia burgdorferi display a spectrum of associated symptoms and severity, strongly implicating the impact of genetically determined host factors in the pathogenesis of Lyme disease. Herein, we provide a summary of the host genetic factors that have been demonstrated to influence the severity and chronicity of Lyme arthritis symptoms, and a review of the resources available, current progress, and added value of a forward genetic approach for identification of novel genetic regulators.
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