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2014 update on atopic dermatitis in children
Christine R Totri1, Lucia Diaz, Lawrence F Eichenfield
1aUniversity of California, San Diego, La Jolla bRady Children's Hospital, San Diego, California, USA.
Insights
Pediatric atopic dermatitis (AD) is increasingly common, with new research expanding understanding of its causes and management. Advances offer preventive strategies, but further work is needed for optimal patient care.
Area of Science:
- Dermatology
- Immunology
- Pediatrics
Background:
- Pediatric atopic dermatitis (AD) prevalence is rising globally, affecting 10-20% of children in developed nations.
- AD significantly impacts healthcare, requiring optimized understanding and management by various specialists.
- The condition is increasingly linked to non-atopic comorbidities like attention deficit hyperactivity disorder.
Purpose of the Study:
- To review recent breakthroughs in the diagnosis, pathophysiology, and management of pediatric atopic dermatitis.
- To highlight the evolving understanding of genetic, immunological, and environmental factors in AD development.
- To discuss innovative, preventive approaches to AD care.
Main Methods:
- Review of current scientific literature on pediatric atopic dermatitis.
- Synthesis of findings from basic, translational, and clinical research.
- Analysis of emerging treatment strategies, including biological agents.
Main Results:
- Expanded knowledge of AD comorbidities, including non-atopic conditions.
- Comprehensive understanding of genetic, immunological, and environmental influences on AD.
- Development of innovative, preventive care strategies for AD management.
- The role of biological agents in AD treatment requires further elucidation.
Conclusions:
- Recent breakthroughs have advanced the diagnosis, pathophysiology, and management of pediatric AD.
- Despite progress, continued research is essential for ensuring optimal care for all individuals with AD.
Purpose Of Review:
The prevalence of pediatric atopic dermatitis (AD) has increased throughout the world, now ranging from 10 to 20% in developed countries. Pediatric patients with AD make up a substantial proportion of patients seen by general pediatricians, allergists, dermatologists, and other specialists. As such, there is a need to optimize understanding and management of AD.
Recent Findings:
The traditional atopic comorbidities of AD have now expanded to include associations with nonatopic conditions such as attention deficit hyperactivity disorder. Furthermore, with insights from basic, translational, and clinical research, experts have a more comprehensive knowledge of the genetic, immunological, and environmental factors influencing the development of AD. With this new perception, innovative approaches to the management of AD have developed with an emphasis on preventive rather than reactive care. The role of biological agents in the treatment of this common, yet chronic, disease of the skin has not been clearly elucidated.
Summary:
There have been several recent breakthroughs in the diagnosis, pathophysiology, and management of AD. Despite these advances, much work is still needed in order to ensure optimal care for AD sufferers.
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