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Related Concept Videos

Diabetic Ketoacidosis l: Introduction01:25

Diabetic Ketoacidosis l: Introduction

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DefinitionDiabetic ketoacidosis (DKA) is an acute, life-threatening complication of diabetes mellitus, characterized by a triad of hyperglycemia (blood glucose >250 mg/dL), ketonemia or ketonuria, and metabolic acidosis (arterial pH <7.30 and serum bicarbonate <18 mEq/L). It results from insulin deficiency combined with elevated levels of counterregulatory hormones—glucagon, catecholamines, cortisol, and growth hormone—leading to increased lipolysis, hepatic...
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Disorders of Leukocytes01:27

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Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
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Diabetic Ketoacidosis ll: Pathophysiology01:22

Diabetic Ketoacidosis ll: Pathophysiology

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Diabetic ketoacidosis (DKA) is a metabolic emergency characterized by hyperglycemia, ketonemia, and metabolic acidosis. It results from severe insulin deficiency and an excess of counterregulatory hormones, leading to uncontrolled lipolysis, ketogenesis, and widespread electrolyte and fluid disturbances.Pathophysiology The central event in DKA is a profound loss of insulin action. Without insulin, glucose uptake in insulin-dependent tissues is impaired, while hepatic glucose production...
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Diagnosing Acidosis and Alkalosis01:24

Diagnosing Acidosis and Alkalosis

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Diagnosing acid-base imbalances involves systematically analyzing arterial blood samples, focusing on three key measurements: pH, bicarbonate (HCO3−) concentration, and carbon dioxide partial pressure (PCO2). This analysis follows a four-step process that helps identify the imbalance's underlying cause and nature.
First, the pH level is assessed to determine whether the blood pH is normal (7.35–7.45), low (acidosis), or high (alkalosis).
Next, the PCO2  and...
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Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
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Updated: Apr 28, 2026

Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
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[Severe lactic acidosis revealing hematologic malignancy].

A Ouchikhe1, J-L Le Bivic1, O Longuet1

  • 1Service de réanimation polyvalente, centre hospitalier Saintonge, 11, boulevard Ambroise-Paré, 17100 Saintes, France.

Annales Francaises D'Anesthesie Et De Reanimation
|June 15, 2014
PubMed
Summary
This summary is machine-generated.

A 75-year-old woman with sepsis developed persistent lactic acidosis. This was ultimately diagnosed as type B lactic acidosis caused by Epstein-Barr virus (EBV)-induced B-cell lymphoma.

Keywords:
Acidose lactiqueEpstein-Barr virusHematologic malignancyHémopathieLactic acidosisVirus d’Epstein-Barr

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Area of Science:

  • Oncology
  • Hematology
  • Critical Care Medicine

Background:

  • Sepsis and cholecystitis are common critical care presentations.
  • Lactic acidosis is a frequent complication in critically ill patients, often indicating poor prognosis.

Observation:

  • A 75-year-old female presented with sepsis, initially treated for cholecystitis.
  • Despite antibiotics, cholecystectomy, and hemofiltration, severe lactic acidosis persisted, suggesting an alternative diagnosis.
  • Further investigation revealed Epstein-Barr virus (EBV)-induced B-cell lymphoma.

Findings:

  • The case highlights a rare presentation of type B lactic acidosis secondary to malignancy.
  • B-cell lymphoma, particularly EBV-induced, can manifest with severe metabolic derangements.
  • Diagnostic challenges in critically ill patients require consideration of unusual etiologies.

Implications:

  • This case underscores the importance of considering malignancy as a cause of refractory lactic acidosis in sepsis.
  • Early suspicion and diagnosis of underlying lymphoma are crucial for appropriate management and improved patient outcomes.
  • Highlights the complex interplay between infection, critical illness, and hematologic malignancies.