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Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications
Published on: November 17, 2015
17.7K
Solid lipid excipients - matrix agents for sustained drug delivery.
Yvonne Rosiaux1, Vincent Jannin1, Sophie Hughes1
1Gattefossé S.A.S., 36 chemin de Genas, BP 603, 69804 Saint-Priest, France.
Summary
Lipid excipients enhance drug delivery systems, offering versatile options for sustained release formulations. This review analyzes their role in manufacturing, release mechanisms, and stability for robust medicines.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- Lipid excipients are increasingly utilized in drug development for their performance and versatility.
- They offer opportunities for intellectual property generation through innovative drug delivery solutions, especially for modified release systems.
Purpose of the Study:
- To provide a comprehensive review of lipid excipients in solid sustained drug delivery systems.
- To analyze key information regarding their efficiency and robustness in formulation.
Main Methods:
- Literature review focusing on lipid excipients in matrix modified release dosage forms.
- Analysis of manufacturing processes, drug release mechanisms, formulation stability, and long-term stability.
Main Results:
- Lipid excipients are effective in developing matrix modified release dosage forms across various processing techniques.
- Understanding lipid excipient functionality is crucial for developing robust lipid-based sustained release medicines.
Conclusions:
- Lipid excipients are valuable tools for creating advanced drug delivery systems.
- Further research into their application can lead to more effective and stable sustained-release medications.
Keywords:
Drug release predictionEthanol effectIn vitro – in vivo correlationLipid excipientProcess technologyStabilityMore Related Videos
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