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A replication study and a meta-analysis of the association between the CDKN2A rs1333049 polymorphism and coronary

Jiangfang Lian1, Yanna Ba, Dongjun Dai

  • 1Ningbo Medical Center, Lihuili Hospital, Department of Cardiology, Ningbo University.

Journal of Atherosclerosis and Thrombosis
|June 17, 2014
PubMed

Insights

The rs1333049 genetic variant is associated with an increased risk of coronary heart disease (CHD) in Han Chinese individuals. This finding was supported by both a case-control study and a comprehensive meta-analysis.

Area of Science:

  • Genetics
  • Cardiovascular Disease Epidemiology

Background:

  • Coronary heart disease (CHD) remains a leading cause of mortality worldwide.
  • Identifying genetic risk factors is crucial for understanding CHD pathogenesis and developing preventative strategies.

Purpose of the Study:

  • To investigate the association between the rs1333049 single nucleotide polymorphism (SNP) and the risk of coronary heart disease (CHD) specifically in the Han Chinese population.
  • To conduct a meta-analysis to consolidate evidence on the contribution of rs1333049 to CHD risk across diverse populations.

Main Methods:

  • A case-control study involving 599 CHD patients and 591 non-CHD controls from the Han Chinese population.
  • A comprehensive meta-analysis incorporating 21 studies (25 stages) with 20,969 CHD cases and 34,114 controls.

Main Results:

  • The case-control study found that rs1333049 significantly increased CHD risk by 38% (OR=1.38).
  • Subgroup analyses revealed a higher risk increase in women (64%) compared to men (29%), and significant associations were observed in specific age groups.
  • The meta-analysis confirmed rs1333049 as a risk factor for CHD (OR=1.30), with increased risk observed in both Europeans (30%) and Asians (27%).

Conclusions:

  • The rs1333049 SNP is a significant risk marker for coronary heart disease.
  • This genetic variant contributes to CHD risk across different ethnicities and genders, highlighting its potential utility in risk assessment.
Abstract

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