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Related Concept Videos

Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

671
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
671
Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate01:25

Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate

142
The glomerular filtration rate (GFR) is a critical indicator of kidney health, reflecting how well the kidneys filter blood. Changes in GFR can signal potential kidney impairment, necessitating accurate measurement methods to monitor kidney function effectively.Various molecules can serve as markers for GFR measurement, with the ideal marker meeting several specific criteria. It must freely filter at the glomerulus, avoid reabsorption or secretion by the renal tubules, remain unmetabolized, not...
142
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

584
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
584
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

337
Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
337
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

408
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
408
Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance01:25

Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance

369
In healthy individuals, serum creatinine levels remain stable due to a balance between its constant production—primarily from muscle metabolism—and renal excretion. Creatinine is freely filtered by the glomeruli, making it a valuable marker for estimating renal function. When the glomerular filtration rate (GFR) decreases, the kidneys can only eliminate less creatinine, causing serum levels to rise.Serum creatinine concentration is widely used to estimate creatinine clearance...
369

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Updated: Apr 28, 2026

Quantitative Real-Time PCR Evaluation of microRNA Expressions in Mouse Kidney with Unilateral Ureteral Obstruction
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The serum uromodulin level is associated with kidney function.

Lorenz Risch, Karl Lhotta, Dominik Meier

    Clinical Chemistry and Laboratory Medicine
    |June 17, 2014
    PubMed
    Summary
    This summary is machine-generated.

    Serum uromodulin levels decrease as kidney function declines, unlike traditional markers. Lower serum uromodulin may indicate reduced kidney cell function in chronic kidney disease.

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    Area of Science:

    • Nephrology
    • Biochemistry
    • Gerontology

    Background:

    • Urinary uromodulin excretion typically decreases with glomerular filtration rate in chronic kidney diseases.
    • Serum uromodulin's association with kidney function requires further investigation.

    Purpose of the Study:

    • To investigate the relationship between serum uromodulin levels and kidney function in older adults.
    • To assess how serum uromodulin correlates with established kidney function markers.

    Main Methods:

    • Serum uromodulin measured via ELISA in individuals aged 60+ from the Seniorlabor study.
    • Analysis of serum uromodulin across various estimated glomerular filtration rate (eGFR) stages.
    • Correlation assessment with creatinine, cystatin C, and urea levels.

    Main Results:

    • Serum uromodulin levels significantly differed across kidney function stages (p<0.001).
    • Inverse correlations observed between serum uromodulin and creatinine (r=-0.39), cystatin C (r=-0.42), and urea (r=-0.30).
    • Positive correlation found between serum uromodulin and eGFRCysC (r=0.38), independent of covariates.

    Conclusions:

    • Serum uromodulin concentrations decrease with declining kidney function, opposing conventional retention markers.
    • Lower serum uromodulin may signify diminished function or number of thick ascending limb cells in chronic kidney disease.