Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

261
Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum...
261
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

206
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
206
Hypersensitivity Reactions: Delayed Hypersensitivity Reactions01:29

Hypersensitivity Reactions: Delayed Hypersensitivity Reactions

353
Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
353
Hypersensitivities01:30

Hypersensitivities

7.2K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
7.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An Uncommon Reaction to a Common Medication: Stevens-Johnson Syndrome Associated With Azithromycin.

Military medicine·2025
Same author

The combination of allergen immunotherapy and biologics for inhalant allergies.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2025
Same author

The Challenges of Delivering Allergen Immunotherapy in the Military Health System.

Federal practitioner : for the health care professionals of the VA, DoD, and PHS·2024
Same author

Cefepime-Induced Generalized Fixed Drug Eruption With Morbilliform Rash.

Cureus·2024
Same author

Imported fire ant immunotherapy.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2024
Same author

Editorial on extended intervals for imported fire ant maintenance immunotherapy: The FIRES study.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2023

Related Experiment Video

Updated: Apr 28, 2026

Potentiodynamic Corrosion Testing
08:43

Potentiodynamic Corrosion Testing

Published on: September 4, 2016

17.7K

Metal hypersensitivity in total joint arthroplasty.

Michelle L Pinson1, Christopher A Coop1, Charles N Webb1

  • 1Department of Medicine, Allergy/Immunology Division, Wilford Hall Ambulatory Surgical Center, San Antonio, Texas.

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
|June 18, 2014
PubMed
Summary

Hypersensitivity reactions to total joint arthroplasty (TJA) implants are increasing. Evaluation requires a systematic approach including history, skin testing, and in vitro studies to guide treatment and future procedures.

More Related Videos

Biotribological Testing and Analysis of Articular Cartilage Sliding against Metal for Implants
09:08

Biotribological Testing and Analysis of Articular Cartilage Sliding against Metal for Implants

Published on: May 14, 2020

3.6K
Protocol for the Evaluation of MRI Artifacts Caused by Metal Implants to Assess the Suitability of Implants and the Vulnerability of Pulse Sequences
08:19

Protocol for the Evaluation of MRI Artifacts Caused by Metal Implants to Assess the Suitability of Implants and the Vulnerability of Pulse Sequences

Published on: May 17, 2018

9.7K

Related Experiment Videos

Last Updated: Apr 28, 2026

Potentiodynamic Corrosion Testing
08:43

Potentiodynamic Corrosion Testing

Published on: September 4, 2016

17.7K
Biotribological Testing and Analysis of Articular Cartilage Sliding against Metal for Implants
09:08

Biotribological Testing and Analysis of Articular Cartilage Sliding against Metal for Implants

Published on: May 14, 2020

3.6K
Protocol for the Evaluation of MRI Artifacts Caused by Metal Implants to Assess the Suitability of Implants and the Vulnerability of Pulse Sequences
08:19

Protocol for the Evaluation of MRI Artifacts Caused by Metal Implants to Assess the Suitability of Implants and the Vulnerability of Pulse Sequences

Published on: May 17, 2018

9.7K

Area of Science:

  • Orthopedic Surgery
  • Allergy and Immunology
  • Biomaterials Science

Background:

  • Total joint arthroplasty (TJA) procedures are increasingly common.
  • Hypersensitivity reactions to TJA implants are a growing concern.
  • The relationship between metal sensitivity and prosthesis failure is not fully understood.

Purpose of the Study:

  • To review clinical manifestations of hypersensitivity reactions to TJA.
  • To evaluate current testing methods for metal hypersensitivity.
  • To discuss treatment options for TJA hypersensitivity.

Main Methods:

  • Literature search of MEDLINE and key article references.
  • Inclusion of randomized controlled trials, systematic reviews, meta-analyses, case series, and observational studies.
  • Focus on studies relevant to clinical practice and metal hypersensitivity.

Main Results:

  • Hypersensitivity reactions to TJA implants are rising.
  • Patch testing is the primary method for metal hypersensitivity, but standardized panels for TJA are lacking.
  • In vitro testing shows promise but has clinical limitations.
  • Pre-operative testing is recommended for patients with a history of metal sensitivity.
  • Surgical revision may be necessary for hypersensitivity-related joint failure.

Conclusions:

  • A systematic approach is crucial for evaluating TJA hypersensitivity.
  • This approach includes detailed patient history and targeted testing.
  • Skin testing and in vitro studies are key components of the evaluation process.