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Related Concept Videos

Allergic Drug Reactions01:27

Allergic Drug Reactions

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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
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Combined Effects of Drugs: Synergism01:27

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Granulocyte-dependent Autoantibody-induced Skin Blistering
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Cefepime-Induced Generalized Fixed Drug Eruption With Morbilliform Rash.

Grayson P Clark1, Haley M Caldwell2, Christopher A Coop3

  • 1Medicine, F. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, USA.

Cureus
|February 27, 2024
PubMed
Summary
This summary is machine-generated.

Fixed drug eruption (FDE) is a recurring skin reaction. A generalized FDE caused by cefepime resolved with drug cessation and standard treatments.

Keywords:
cd8+ t cell activationcefepimefixed drug eruptionsmorbilliform rashviolaceous patches

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Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Fixed drug eruption (FDE) is a specific type of adverse drug reaction characterized by recurrent, localized skin lesions upon re-exposure to an inciting agent.
  • FDEs typically manifest as violaceous plaques, often with subsequent hyperpigmentation, and can be triggered by various medications including antibiotics, NSAIDs, and anticonvulsants.

Observation:

  • This report details a case of a generalized fixed drug eruption.
  • The eruption was a severe, widespread reaction attributed to the antibiotic cefepime.

Findings:

  • The generalized fixed drug eruption secondary to cefepime demonstrated characteristic recurrence patterns.
  • Resolution was achieved by discontinuing the causative drug, cefepime.
  • Supportive treatment with antihistamines and topical corticosteroids aided in the management of the cutaneous reaction.

Implications:

  • This case highlights cefepime as a potential trigger for generalized fixed drug eruptions.
  • It underscores the importance of prompt drug withdrawal and symptomatic treatment for managing severe FDE.
  • Clinicians should consider FDE in the differential diagnosis of widespread drug-induced skin reactions, particularly with antibiotics like cefepime.